实用皮肤病学杂志
實用皮膚病學雜誌
실용피부병학잡지
Journal of Practical Dermatology
2015年
5期
348-350
,共3页
杜金锋%裴广德%甄希%杜军波
杜金鋒%裴廣德%甄希%杜軍波
두금봉%배엄덕%견희%두군파
白癜风%吡美莫司%他卡西醇
白癜風%吡美莫司%他卡西醇
백전풍%필미막사%타잡서순
Vitiligo%Pimecrolimus%Tacalcitol
目的:观察吡美莫司乳膏联合他卡西醇软膏治疗局限性白癜风的疗效和安全性。方法将91例局限性白癜风患者随机分为试验组(46例)和对照组(45例)。两组患者均早晚外用吡美莫司乳膏各1次;试验组每日中午外用他卡西醇软膏1次,总疗程共6个月。在治疗前,治疗第1、2、3和6个月末随访,观察疗效和不良反应。结果治疗第1、2个月末,治疗组有效率(17.39%、34.78%)虽然高于对照组(15.56%、24.44%),但差异均无统计学意义(P>0.05);治疗第3、6个月末,试验组有效率(52.17%、63.04%)均明显高于对照组(31.11%、42.22%),差异均有统计学意义(P<0.05)。两组均未出现严重不良反应。结论吡美莫司乳膏联合他卡西醇软膏治疗局限性白癜风疗效确切,安全方便,治疗费用较低,且不良反应少。
目的:觀察吡美莫司乳膏聯閤他卡西醇軟膏治療跼限性白癜風的療效和安全性。方法將91例跼限性白癜風患者隨機分為試驗組(46例)和對照組(45例)。兩組患者均早晚外用吡美莫司乳膏各1次;試驗組每日中午外用他卡西醇軟膏1次,總療程共6箇月。在治療前,治療第1、2、3和6箇月末隨訪,觀察療效和不良反應。結果治療第1、2箇月末,治療組有效率(17.39%、34.78%)雖然高于對照組(15.56%、24.44%),但差異均無統計學意義(P>0.05);治療第3、6箇月末,試驗組有效率(52.17%、63.04%)均明顯高于對照組(31.11%、42.22%),差異均有統計學意義(P<0.05)。兩組均未齣現嚴重不良反應。結論吡美莫司乳膏聯閤他卡西醇軟膏治療跼限性白癜風療效確切,安全方便,治療費用較低,且不良反應少。
목적:관찰필미막사유고연합타잡서순연고치료국한성백전풍적료효화안전성。방법장91례국한성백전풍환자수궤분위시험조(46례)화대조조(45례)。량조환자균조만외용필미막사유고각1차;시험조매일중오외용타잡서순연고1차,총료정공6개월。재치료전,치료제1、2、3화6개월말수방,관찰료효화불량반응。결과치료제1、2개월말,치료조유효솔(17.39%、34.78%)수연고우대조조(15.56%、24.44%),단차이균무통계학의의(P>0.05);치료제3、6개월말,시험조유효솔(52.17%、63.04%)균명현고우대조조(31.11%、42.22%),차이균유통계학의의(P<0.05)。량조균미출현엄중불량반응。결론필미막사유고연합타잡서순연고치료국한성백전풍료효학절,안전방편,치료비용교저,차불량반응소。
ObjectiveTo observe the clinical efifcacy and safety of pimecrolimus cream combined with tacalcitol ointment in the treatment of localized vitiligo.MethodsA total of 91 patients with localized vitiligo were randomly divided into treatment group (n=46) and control group (n=45). Both the two groups were topically treated with pimecrolimus cream twice daily in the morning and night respectively for 6 months. In addition, the treatment group was topically treated with tacalcitol ointment once every noon. All patients were followed-up for 6 months, and the clinical efficacy was evaluated before treatment and at 1, 2, 3 and 6 months of the treatment respectively.ResultsThe effective rates of the treatment group (17.39%, 34.78%) were higher than the control group(15.56%, 24.44%) respectively at the ends of the 1th and 2th month after treatment, but there were no statistical signiifcance (P>0.05). The effective rates of the treatment group (52.17%, 63.04%) were signiifcantly higher than those of the control group (31.11%, 42.22%) at the ends of the 3th and 6th month after treatment respectively (P<0.05). No serious adverse reactions occurred in the two groups during the experiment.ConclusionThe treatment of pimecrolimus cream combined with tacalcitol ointment is effective, safe and convenient in the treatment of localized vitiligo, meanwhile with low cost and less adverse reaction.