CAJ | 학술논문

目的：探讨我国肿胀性红斑狼疮患者的临床表现、组织病理特点、治疗以及预后，以提高对本病的认识。方法收集2009—2014年笔者确诊的6例肿胀性红斑狼疮及自2003年中国报道的13例患者的临床资料，并进行回顾性总结分析。结果19例患者中女9例，男10例；平均发病年龄38.1岁。临床特点主要为曝光部位出现水肿性红斑，少数发生在腰背部等非曝光部位。2例患者伴有脱发。组织病理主要表现为真皮全层的血管附属器周围淋巴细胞浸润及纤维束之间的黏蛋白沉积。羟氯喹及联合糖皮质激素口服治疗有效。结论肿胀性红斑狼疮是慢性皮肤型红斑狼疮的一个亚型，临床表现相对单一，没有统一诊断标准，目前对该病的认识不足，导致患者病情迁徙、误诊、误治。因此有必要提高对该病的认识，以便给予患者正确的诊断及有效的治疗。
목적：탐토아국종창성홍반랑창환자적림상표현、조직병리특점、치료이급예후，이제고대본병적인식。방법수집2009—2014년필자학진적6례종창성홍반랑창급자2003년중국보도적13례환자적림상자료，병진행회고성총결분석。결과19례환자중녀9례，남10례；평균발병년령38.1세。림상특점주요위폭광부위출현수종성홍반，소수발생재요배부등비폭광부위。2례환자반유탈발。조직병리주요표현위진피전층적혈관부속기주위림파세포침윤급섬유속지간적점단백침적。간록규급연합당피질격소구복치료유효。결론종창성홍반랑창시만성피부형홍반랑창적일개아형，림상표현상대단일，몰유통일진단표준，목전대해병적인식불족，도치환자병정천사、오진、오치。인차유필요제고대해병적인식，이편급여환자정학적진단급유효적치료。
ObjectiveTo explore the clinical and pathologic character, treatment strategy and prognoses of lupus erythematosus tumidus (LET).MethodSix cases of LET diagnosed by the author, from 2009 to 2014, as well as other 13 cases reported in China were collected, and the clinical and pathological data were analysed (the other 4 patients unable to track the details were excluded in this retrospective analysis).ResultsThere were 9 males and 10 females among the 19 patients with TC who were aged from 19 to 58 years (mean age: 38.1 years). Clinically, the skin lesions mainly presented on the sun-exposed areas, minority of the skin lesions were distributed on the un-sun-exposed areas. There were 2 cases complicated with alopecia. Histopathology features include: lymphocytic, perivascular and periadnexal inifltrate with abundant interstitial, superifcial, and deep dermal mucin deposition without appreciable epidermal and vacuolar changes. Typically, LET is responsive to the treatment of systemic antimalarials. ConclusionLET is a special form of chronic cutaneous lupus erythematosus. The clinical manifestation of LET is relatively special and has no uniifed diagnostic criteria. The lack of understanding of the disease led to the misdiagnosis and deferment of the symptoms in patients. It is necessary to improve the understanding of LET, so as to give the correct diagnosis and effective treatment.