CAJ | 학술논문

目的：探讨胃癌组织中Foxp3＋调节性T细胞（Foxp3＋Tregs）与程序性死亡受体1（PD1）的表达情况及两者与胃癌患者临床病理和预后的关系。方法：采用免疫组织化学方法检测111例胃癌患者癌组织和20例正常胃黏膜组织中Foxp3＋Tregs及PD1的表达情况，分析胃癌组织中两者的表达与患者临床病理和预后的关系及两项指标之间的相关性。结果：胃癌组织中Foxp3＋Tregs 和PD1表达增加， PD1表达于肿瘤浸润性淋巴细胞（TILs），两者的表达均与淋巴结转移及TNM分期相关（P＜0．05），而与其它临床病理因素如肿瘤大小、病理类型，病变部位均无关，以上指标表达阳性者总体生存率低（P＜0．05），预后差。胃癌组织中Foxp3＋Tregs与PD1＋TILs的表达之间存在显著的正相关（ P＜0．01）。结论：胃癌组织中存在Foxp3＋Tregs和PD1＋TILs共同表达，二者可作为判断胃癌患者疾病进展及预后的生物学标志物。
목적：탐토위암조직중Foxp3＋조절성T세포（Foxp3＋Tregs）여정서성사망수체1（PD1）적표체정황급량자여위암환자림상병리화예후적관계。방법：채용면역조직화학방법검측111례위암환자암조직화20례정상위점막조직중Foxp3＋Tregs급PD1적표체정황，분석위암조직중량자적표체여환자림상병리화예후적관계급량항지표지간적상관성。결과：위암조직중Foxp3＋Tregs 화PD1표체증가， PD1표체우종류침윤성림파세포（TILs），량자적표체균여림파결전이급TNM분기상관（P＜0．05），이여기타림상병리인소여종류대소、병리류형，병변부위균무관，이상지표표체양성자총체생존솔저（P＜0．05），예후차。위암조직중Foxp3＋Tregs여PD1＋TILs적표체지간존재현저적정상관（ P＜0．01）。결론：위암조직중존재Foxp3＋Tregs화PD1＋TILs공동표체，이자가작위판단위암환자질병진전급예후적생물학표지물。
AIM:ToinvestigatetheexpressionofFoxp3+regulatoryTcells(Foxp3+Tregs)andprogrammed death receptor 1 (PD1) in gastric cancer tissues and their association with clinicopathological factors and prognosis of the patients.The correlation between the 2 molecules was also analyzed at the same time.METHODS: The tumor sections from 111 gastric cancer patients were stained for Foxp3 and PD1 by the method of immunohistochemistry.The associations of the expression levels of these 2 molecules with clinicopathological factors involved in the disease progression and progno-sis were statistically analyzed .The relationship of their expression was detected.RESULTS:Foxp3 +Tregs and PD1 were expressed in the gastric cancer tissues, and PD1 was expressed in the tumor infiltrating lymphocytes ( TILs) .The expres-sion of Foxp3 and PD1 was correlated with lymph node metastasis, clinicopathological stage and prognosis of gastric cancer patients.The expression of these 2 determinants in the patients with lymph node metastasis and an advanced clinicopatho-logical stage was distinctly higher ( P<0.05 ) .The patients with positive expression of the 2 indexes presented a lower overall survival rate and worse prognosis (P<0.05).A significantly positive correlation between the infiltration of Foxp3 +Tregs and the expression of PD1+TILs was also observed (P<0.01).CONCLUSION:Foxp3 +Tregs and PD1 +TILs co-infiltrate in the gastric cancer tissues, which can be used as biological markers to predict the disease progression and prog-nosis.