CAJ | 학술논문

分子靶向治疗指使用单克隆抗体、多肽等物质特异性干预调节肿瘤细胞生物学行为的信号通路，从而达到抑制肿瘤生长的目的。临床实践证明分子靶向治疗对乳腺肿瘤治疗已经取得显著的疗效作用。从乳腺癌治疗的相关靶点及靶向药物治疗的研究进展进行综述，包括针对人类表皮生长因子受体－2（ HER－2）、表皮生长因子受体（EGFR）、血管内皮生长因子（VEGF）和针对多靶点的靶向药物及其作用机制，最后介绍了临床发现治疗乳腺癌的联合用药和用药过后产生的耐药机制研究进展。
분자파향치료지사용단극륭항체、다태등물질특이성간예조절종류세포생물학행위적신호통로，종이체도억제종류생장적목적。림상실천증명분자파향치료대유선종류치료이경취득현저적료효작용。종유선암치료적상관파점급파향약물치료적연구진전진행종술，포괄침대인류표피생장인자수체－2（ HER－2）、표피생장인자수체（EGFR）、혈관내피생장인자（VEGF）화침대다파점적파향약물급기작용궤제，최후개소료림상발현치료유선암적연합용약화용약과후산생적내약궤제연구진전。
Molecular targeted therapy utilizes monoclonal antibody and polypeptide, etc., to specifically target the key signal pathways involved in the regulation of the malignant behaviors of tumor cells to inhibit the tumor growth.It has achieved a remarkable clinical efficacy in the treatment of breast cancer.This article reviews the related treatment targets for breast cancer, the advances on targeted drugs, like those against human epidermal growth factor receptor-2 ( HER-2 ) , epidermal growth factor receptor ( EGFR) , vascular endothelial growth factor ( VEGF) and those focusing on multiple targets, and the action mechanism.The combination of drugs for the treatment of breast cancer and drug-resistant mechanisms are elucidated as well.