医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
Journal of Medical Molecular Biology
2015年
5期
277-280
,共4页
林大为%于德安%李勐%回鹏
林大為%于德安%李勐%迴鵬
림대위%우덕안%리맹%회붕
垂体腺瘤%MMP-14%VEGF
垂體腺瘤%MMP-14%VEGF
수체선류%MMP-14%VEGF
pituitary adenoma%matrix metalloproteinase-14 ( MMP-14 )%vascular endothelial growth factor ( VEGF)
目的：探讨侵袭性垂体腺瘤患者临床特征与其侵袭性关系，垂体腺瘤组织中基质金属蛋白酶－14（matrix metalloproteinases－14， MMP－14）、血管内皮生长因子（vascular endothelial growth factor， VEGF）表达水平与肿瘤侵袭性关系。方法选取2012年1月至2014年7月来我院治疗的96例垂体腺瘤患者为研究对象，50例非侵袭性垂体腺瘤，46例侵袭性垂体腺瘤，免疫组化法测定组织中MMP－14、 VEGF表达水平，分析其与肿瘤侵袭性的相关性。结果侵袭性垂体腺瘤组织中MMP－14、 VEGF强阳性表达率为28．26％、52．17％，总阳性表达率为65．22％、95．65％，显著高于非侵袭性垂体腺瘤组织中MMP－14、 VEGF强阳性表达率（14．00％、20．00％）及总阳性表达率（42．00％、56．00％）（P均＜0．05）； MMP－14、 VEGF为阳性情况下侵袭性垂体腺瘤体积、最大径显著高于非侵袭性组（P均＜0．05）， MMP－14、 VEGF为阴性情况下侵袭性垂体腺瘤与非侵袭性组，比较差异均无统计学意义（P＞0．05）；经相关性分析，侵袭性垂体腺瘤患者MMP－14与VEGF表达水平呈正相关（r＝0．726， P＜0．01）。结论侵袭性垂体腺瘤组织中MMP－14与VEGF表达增高， MMP－14与VEGF可作为辅助垂体腺瘤侵袭性判断生物学指标。
目的：探討侵襲性垂體腺瘤患者臨床特徵與其侵襲性關繫，垂體腺瘤組織中基質金屬蛋白酶－14（matrix metalloproteinases－14， MMP－14）、血管內皮生長因子（vascular endothelial growth factor， VEGF）錶達水平與腫瘤侵襲性關繫。方法選取2012年1月至2014年7月來我院治療的96例垂體腺瘤患者為研究對象，50例非侵襲性垂體腺瘤，46例侵襲性垂體腺瘤，免疫組化法測定組織中MMP－14、 VEGF錶達水平，分析其與腫瘤侵襲性的相關性。結果侵襲性垂體腺瘤組織中MMP－14、 VEGF彊暘性錶達率為28．26％、52．17％，總暘性錶達率為65．22％、95．65％，顯著高于非侵襲性垂體腺瘤組織中MMP－14、 VEGF彊暘性錶達率（14．00％、20．00％）及總暘性錶達率（42．00％、56．00％）（P均＜0．05）； MMP－14、 VEGF為暘性情況下侵襲性垂體腺瘤體積、最大徑顯著高于非侵襲性組（P均＜0．05）， MMP－14、 VEGF為陰性情況下侵襲性垂體腺瘤與非侵襲性組，比較差異均無統計學意義（P＞0．05）；經相關性分析，侵襲性垂體腺瘤患者MMP－14與VEGF錶達水平呈正相關（r＝0．726， P＜0．01）。結論侵襲性垂體腺瘤組織中MMP－14與VEGF錶達增高， MMP－14與VEGF可作為輔助垂體腺瘤侵襲性判斷生物學指標。
목적：탐토침습성수체선류환자림상특정여기침습성관계，수체선류조직중기질금속단백매－14（matrix metalloproteinases－14， MMP－14）、혈관내피생장인자（vascular endothelial growth factor， VEGF）표체수평여종류침습성관계。방법선취2012년1월지2014년7월래아원치료적96례수체선류환자위연구대상，50례비침습성수체선류，46례침습성수체선류，면역조화법측정조직중MMP－14、 VEGF표체수평，분석기여종류침습성적상관성。결과침습성수체선류조직중MMP－14、 VEGF강양성표체솔위28．26％、52．17％，총양성표체솔위65．22％、95．65％，현저고우비침습성수체선류조직중MMP－14、 VEGF강양성표체솔（14．00％、20．00％）급총양성표체솔（42．00％、56．00％）（P균＜0．05）； MMP－14、 VEGF위양성정황하침습성수체선류체적、최대경현저고우비침습성조（P균＜0．05）， MMP－14、 VEGF위음성정황하침습성수체선류여비침습성조，비교차이균무통계학의의（P＞0．05）；경상관성분석，침습성수체선류환자MMP－14여VEGF표체수평정정상관（r＝0．726， P＜0．01）。결론침습성수체선류조직중MMP－14여VEGF표체증고， MMP－14여VEGF가작위보조수체선류침습성판단생물학지표。
Objective To investigate the relationship between clinical features of invasive pitu-itary adenoma and its invasiveness, and between the expression levels of matrix metalloproteinase-14 ( MMP-14) and vascular endothelial growth factor ( VEGF) and the invasiveness of pituitary adeno-mas.Methods A total of 96 patients with pituitary adenoma who were treated between January 2012 and July 2014 in our hospital were examined.There were 46 cases of invasive pituitary adeno-ma and 50 cases of non-invasive pituitary adenoma.The expression levels of MMP-14 and VEGF were immunohistochemically detected, and the association of their expression levels with tumor inva-siveness was analyzed.Results In invasive pituitary adenomas, the strong positive rates of MMP-14 and VEGF were 28.26% and 52.17%, respectively, and the total positive rates were 65.22 %and 95.65 %, respectively, significantly higher than those in non-invasive pituitary adenomas in which the strong positive rates of MMP-14 and VEGF were 14.00% and 20.00%, respectively, and the total positive rates were 42.00% and 56.00%, respectively ( all P<0.05 ) .The maxi-mum diameter and the volume of invasive pituitary adenomas with positive expressions of MMP-14 and VEGF were significantly greater than those of non-invasive pituitary adenomas ( all P<0.05 ) .No significant difference was noted in the maximum diameter and the volume of pituitary adenomas between invasive pituitary adenomas with negative expressions of MMP-14 and VEGF and non-inva-sive pituitary adenomas ( P>0.05 ) .Correlation analysis revealed that the expression of MMP-14was positively associated with that of VEGF in invasive pituitary adenomas (r=0.734, P<0.01). Conclusion The expressions of MMP-14 and VEGF are increased in invasive pituitary adenomas and they can be used as auxiliary biological indicators for the invasiveness of pituitary adenomas.
