CAJ | 학술논문

目的利用光学相干断层扫描仪(OCT)测量并分析北京市昌平区自然人群黄斑厚度,并分析糖尿病患者是否存在黄斑厚度的增加.方法根据2011年"昌平区卫生与人群健康状况调查",521例受试者(正常血糖233例,糖尿病前期174例,糖尿病114例)完成体格检查和血液生化指标的测定,包括空腹血糖、口服葡萄糖耐量试验(OGTT)-2 h血糖和糖化血红蛋白(HbA1c),并通过OCT检查黄斑厚度.结果男性视网膜黄斑中心凹厚度(《246±22) μm)明显高于女性(《235±26) μm) (P＜0.001).校正性别后,以年龄、HbA1c和身体质量指数(BMI)来划分的各组间黄斑厚度差异均无统计学意义(P＜0.05).不同糖代谢状态的3组受试者黄斑中心凹、内环和外环厚度差异均无统计学意义(P＞0.05).结论男性视网膜黄斑中心凹厚度显著高于女性;年龄、HbA1c和BMI与黄斑中心凹厚度无显著相关性;不同糖代谢状态受试者视网膜厚度间差异无统计学意义(P＞0.05).
목적 이용광학상간단층소묘의(OCT)측량병분석북경시창평구자연인군황반후도,병분석당뇨병환자시부존재황반후도적증가.방법 근거2011년"창평구위생여인군건강상황조사",521례수시자(정상혈당233례,당뇨병전기174례,당뇨병114례)완성체격검사화혈액생화지표적측정,포괄공복혈당、구복포도당내량시험(OGTT)-2 h혈당화당화혈홍단백(HbA1c),병통과OCT검사황반후도.결과 남성시망막황반중심요후도(《246±22) μm)명현고우녀성(《235±26) μm) (P＜0.001).교정성별후,이년령、HbA1c화신체질량지수(BMI)래화분적각조간황반후도차이균무통계학의의(P＜0.05).불동당대사상태적3조수시자황반중심요、내배화외배후도차이균무통계학의의(P＞0.05).결론 남성시망막황반중심요후도현저고우녀성;년령、HbA1c화BMI여황반중심요후도무현저상관성;불동당대사상태수시자시망막후도간차이무통계학의의(P＞0.05).
Objective To measure the macular thickness of natural population in Changping district of Beijing by optical coherence tomography (OCT), and to analyze whether there is an increased thickness in diabetic patients.Methods In a cross-sectional population-based study, OCT was performed on 521 subjects (233 with normal glucose homeostasis, 174 with pre-diabetes and 114 with type 2 diabetes (T2D) according to "2011 Health Examination Survey of Changping".The subjects also received physical examination and laboratory measurements including fasting plasma glucose (FPG), oral glucose tolerance test (OGTT)-2 h plasma glucose and hemoglobin A1c (HbA1c).Results The results showed that central subfield thickness (CST) of the retina of men ((246±22) μm) was significantly greater than that of women ((235±26) μm) (P＜0.001).Meanwhile, no significant difference was found in the CST in subjects of different age, HbAlc and body mass index (BMI) (P＞0.05).Difference in thickness of different glucose groups was not seen in central subfield, inner subfields and outer subfields(P＞0.05).Conclusions Retina CST of men was significantly greater than that of women.No significant difference was found in the CST in subjects of different age, HbA1c and BMI.