CAJ | 학술논문

目的应用增强深度成像相干光断层扫描(EDI-OCT)技术观察糖尿病患者有临床意义黄斑水肿(CSME)的中心凹下脉络膜厚度(SFCT)及相关因素分析.方法选取40例正常对照组(A组)、49例2型糖尿病患者不伴CSME组(B组)及37例2型糖尿病患者伴CSME组(C组)纳入本研究,其中男性67例,女性59例.应用海德堡频域OCT对全部研究对象进行EDI-OCT检查.组间SFCT的比较采用单因素方差分析法(ANOVA),以有无CSME为因变量,以相关因素为自变量进行logistic回归分析.CSME的SFCT与患者糖尿病病程、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、尿白蛋白排泄率(UAER)等因素的相关性应用Pearson相关分析.结果 A组的平均SFCT为(271.49±36.18) μm,B组的平均SFCT为(260.48±35.27) μm,2者比较差异无统计学意义(P＞0.05);C组的平均SFCT为(227.90±34.73) μm,与A组比较,差异有统计学意义(P＜0.01);B组与C组比较,差异有统计学意义(P＜0.01).2型糖尿病患者有临床意义黄斑水肿的平均SFCT分别与LDL和UAER具有相关性(r=-0.609、-0.681,P＜0.01),而与患者的糖尿病病程、FBG、HbA1c、TG、TC、HDL、肌酐、收缩压(SBP)及舒张压(DBP)均无相关性(P＞0.05).结论 C组的平均SFCT较A、B组变薄,且C组糖尿病伴CSME患者的LDL和UAER水平与SFCT呈负相关,即随着LDL和UAER水平升高,SFCT呈减低趋势.
목적 응용증강심도성상상간광단층소묘(EDI-OCT)기술관찰당뇨병환자유림상의의황반수종(CSME)적중심요하맥락막후도(SFCT)급상관인소분석.방법 선취40례정상대조조(A조)、49례2형당뇨병환자불반CSME조(B조)급37례2형당뇨병환자반CSME조(C조)납입본연구,기중남성67례,녀성59례.응용해덕보빈역OCT대전부연구대상진행EDI-OCT검사.조간SFCT적비교채용단인소방차분석법(ANOVA),이유무CSME위인변량,이상관인소위자변량진행logistic회귀분석.CSME적SFCT여환자당뇨병병정、공복혈당(FBG)、당화혈홍단백(HbA1c)、감유삼지(TG)、총담고순(TC)、저밀도지단백(LDL)、고밀도지단백(HDL)、뇨백단백배설솔(UAER)등인소적상관성응용Pearson상관분석.결과 A조적평균SFCT위(271.49±36.18) μm,B조적평균SFCT위(260.48±35.27) μm,2자비교차이무통계학의의(P＞0.05);C조적평균SFCT위(227.90±34.73) μm,여A조비교,차이유통계학의의(P＜0.01);B조여C조비교,차이유통계학의의(P＜0.01).2형당뇨병환자유림상의의황반수종적평균SFCT분별여LDL화UAER구유상관성(r=-0.609、-0.681,P＜0.01),이여환자적당뇨병병정、FBG、HbA1c、TG、TC、HDL、기항、수축압(SBP)급서장압(DBP)균무상관성(P＞0.05).결론 C조적평균SFCT교A、B조변박,차C조당뇨병반CSME환자적LDL화UAER수평여SFCT정부상관,즉수착LDL화UAER수평승고,SFCT정감저추세.
Objective To evaluate the correlation of sub-foveal chomidal thickness (SFCT) variation in type 2 diabetic patients with clinically significant diabetic macular edema (CSME) and the related factors using enhanced depth imaging optical coherence tomography technique (EDI-OCT).Methods A total of 40 normal volunteers (group A), 49 type 2 diabetic patients without CSME(group B) and 37 type 2 diabetic patients with CSME (group C) were recruited, including 67 male and 59 female.All study subjects received EDI-OCT examination.The SFCT in A, B and C groups were compared using one-way ANOVA analysis.The correlations between SFCT and duration of diabetes, fasting blood glucose (FBG), glycoseylated hemoglobin HbAlc, low density lipopmtein (LDL), triglyceride (TG), total cholesterol (TC), high density lipopmtein (HDL), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were analyzed using logistic regression analysis.Results Average SFCT in group A was (271.49±36.18) μm.Average SFCT in group B was (260.48±35.27) μm, and compared with group A, the difference was not statistically significant (P＞ 0.05).Average SFCT in group C was (227.90±34.73) μm, and compared with group A, the difference was statistically significant (P＜0.01).There was a significant difference of SFCT between groups B and C (P＜0.01).There was no statistically correlation between average SFCT and duration of diabetes, FBG, HbA1c, TG, TC, HDL, creatinine, SBP and DBP (P＞0.05), while a statistically correlation between SFCT and LDL or urinary albumin excretion rate (UAER) was observed in the study (r=-0.609,-0.681, P＜0.01).Conclusions Compared with groups A and B, SFCT in type 2 diabetic patients with CSME was significantly thinner.UAER and LDL levels in type 2 diabetic patients with CSME were negatively correlated with SFCT, that is to say, with the increasing of UAER and LDL levels, SFCT in type 2 diabetic patients with CSME decreased.