CAJ | 학술논문

目的：通过研究新诊断的2型糖尿病患者平均血糖（MBG）与糖化血红蛋白A1c（HbA1c）及其它代谢、血糖波动指标的关系，分析影响该人群MBG的相关因素。方法：90例来自广东省4家医院的新诊断2型糖尿病患者，检测空腹血糖、血脂、胰岛素及OGTT 2 h血糖、胰岛素，并进行72 h的连续动态血糖监测，计算MBG以及血糖波动参数。结果：血糖波动参数[血糖标准差、平均血糖波动幅度、日间血糖平均绝对差（ MODD）及血糖波动最大幅度（ DMMG）]、HbA1c、空腹血糖以及服糖后2 h血糖均与MBG相关（P＜0．01）；逐步线性回归提示HbA1c、MODD、DMMG及空腹血糖与MBG有最强关联性（P＜0．05）。纳入以上4个指标的线性拟合方程较仅纳入HbA1c的线性拟合方程更精确。结论：影响我国新诊断2型糖尿病患者MBG的因素包括HbA1c、空腹血糖、DMMG以及MODD。在临床上单纯依靠HbA1c推算新诊断2型糖尿病患者的MBG可能存在误差。
목적：통과연구신진단적2형당뇨병환자평균혈당（MBG）여당화혈홍단백A1c（HbA1c）급기타대사、혈당파동지표적관계，분석영향해인군MBG적상관인소。방법：90례래자광동성4가의원적신진단2형당뇨병환자，검측공복혈당、혈지、이도소급OGTT 2 h혈당、이도소，병진행72 h적련속동태혈당감측，계산MBG이급혈당파동삼수。결과：혈당파동삼수[혈당표준차、평균혈당파동폭도、일간혈당평균절대차（ MODD）급혈당파동최대폭도（ DMMG）]、HbA1c、공복혈당이급복당후2 h혈당균여MBG상관（P＜0．01）；축보선성회귀제시HbA1c、MODD、DMMG급공복혈당여MBG유최강관련성（P＜0．05）。납입이상4개지표적선성의합방정교부납입HbA1c적선성의합방정경정학。결론：영향아국신진단2형당뇨병환자MBG적인소포괄HbA1c、공복혈당、DMMG이급MODD。재림상상단순의고HbA1c추산신진단2형당뇨병환자적MBG가능존재오차。
AIM:TodetecthemoglobinA1c(HbA1c)andparametersofbloodglucosefluctuationinChinesenewlydiag-nosed type 2 diabetes mellitus (T2DM) patients, and further to specify the factors that were related to mean blood glucose (MBG) in this population.METHODS:Newly diagnosed T2DM patients (n=90) from 4 hospitals in Guangdong province were enrolled, and subjected to 3 d continuous glucose monitoring (CGM) after testing for HbA1c and other laboratory tests.Blood glucose data collected during CGM were used to calculate MBG and parameters of blood glucose fluctuation.RESULTS: Correlation analysis revealed that MBG was significantly related to all parameters of blood glucose fluctuation, HbA1c, fast plasma glucose ( FPG) and 2 h postprandial glucose (P<0.01), but not to sex, age or blood lipid profile.Further analysis utilizing step-wise general linear model showed that HbA1c, absolute means of daily difference ( MODD) , difference between maximal and minimal glucose ( DMMG) and FPG had the strongest relation to MBG.CONCLUSION: Factors affecting MBG of the newly diagnosed T2DMpatients in our country include HbA1c, FPG, DMMG and MODD, and thus it may be prone to misleading results that only HbA1c is applied to estimate MBG in this population.