CAJ | 학술논문

目的：观察枳术丸联用西药对克罗恩病患者 Th1细胞及 CD8T 细胞平衡状态的影响。方法选择收治的106例克罗恩病患者，随机分为枳术丸结合克罗恩病患者西药综合治疗组（观察组）及单纯克罗恩病患者西药治疗组（对照组），每组53例。治疗结束后，检测 CD8T 细胞群及 T 细胞亚群含量并评定两组患者的临床疗效。结果观察组有效率89.49％，优于对照组有效率72.57％（ P ﹤0.05）。治疗前，两组的 CD8T 细胞总数以及 Tr、Th1的比率比较均无统计学差异（ P ﹥0.05）；治疗后，观察组的 CD8T 细胞总数以及 Th1的比率较对照组增加，而 Tr 的比率则较对照组降低（ P ﹤0.05）。结论枳术丸联用西药治疗克罗恩病患者有效性较好，其机制可能与其促进克罗恩病患者的 Th1细胞分化，逐渐恢复 Th1/ Tr 平衡有关。
목적：관찰지술환련용서약대극라은병환자 Th1세포급 CD8T 세포평형상태적영향。방법선택수치적106례극라은병환자，수궤분위지술환결합극라은병환자서약종합치료조（관찰조）급단순극라은병환자서약치료조（대조조），매조53례。치료결속후，검측 CD8T 세포군급 T 세포아군함량병평정량조환자적림상료효。결과관찰조유효솔89.49％，우우대조조유효솔72.57％（ P ﹤0.05）。치료전，량조적 CD8T 세포총수이급 Tr、Th1적비솔비교균무통계학차이（ P ﹥0.05）；치료후，관찰조적 CD8T 세포총수이급 Th1적비솔교대조조증가，이 Tr 적비솔칙교대조조강저（ P ﹤0.05）。결론지술환련용서약치료극라은병환자유효성교호，기궤제가능여기촉진극라은병환자적 Th1세포분화，축점회복 Th1/ Tr 평형유관。
Objective To observe the influence in Th1 cells and CD8 T cell equilibrium after definite operation pill combination with western medicine for Crohn disease. Methods There are 106 patients with Crohn disease admitted in our department. All patients were randomly divided into Crohn disease western medicine comprehensive treatment in combination with chemotherapy pill group(observation group)and pure western medicine treatment group(control group)in patients with Crohn disease 53 cases in each group. After the treatment,the contents of CD8T cells and T cells subgroup was detected,ratio are calculated. Th1 cells differentiation experiments,observation of r - interferon,IL - 1Β,IL -6,IL - 12 on the induction of Th1 cells,were used to assess the efficacy of the two groups. Results The effective rate in observation group was 89. 49% . The effective rate was better than that of control group 72. 57%( P ﹤ 0. 05). Before the treatment,the total number of CD8 T cells and the proportion of Tr,Th1 in them in the two groups was no statistical difference( P ﹥ 0. 05). After treatment,the total number of observation group CD8T cells and Th1 percentage in the control group increased,and the proportion of the Tr was relatively lower than control( P ﹤ 0. 05). Conclusion Definite operation pill combination of Crohnˊs disease western medicine has good effectiveness in the treatment of Crohn disease. Its mechanism may be and can be produced by the Β,IL - 6,IL - 1 cytokines,thus promotes the Th1 cells of Crohn disease differentiation,gradually restore balance on Th1 / Tr.