CAJ | 학술논문

目的：探讨 miRNA -221在甲状腺乳头状癌中的表达及其与临床病理特征的关系。方法采用逆转录 PCR方法检测 miRNA -221在甲状腺乳头状癌组织以及在正常甲状腺组织样本中的表达，并分析 miRNA -221的表达与甲状腺乳头状癌的临床病理特征的相关性。结果 miRNA -221在甲状腺乳头状癌组织中的表达明显高于正常甲状腺组织（ P﹤0.05），miRNA -221的表达水平与甲状腺乳头状癌组织的病理分级具有显著相关性（ r ＝0.823，P ﹤0.05）。结论miRNA -221在甲状腺乳头状癌组织中表达较高，且与甲状腺乳头状癌组织病理分级有相关性，miRNA -221在甲状腺乳头状癌的发生与发展有重要作用。
목적：탐토 miRNA -221재갑상선유두상암중적표체급기여림상병리특정적관계。방법채용역전록 PCR방법검측 miRNA -221재갑상선유두상암조직이급재정상갑상선조직양본중적표체，병분석 miRNA -221적표체여갑상선유두상암적림상병리특정적상관성。결과 miRNA -221재갑상선유두상암조직중적표체명현고우정상갑상선조직（ P﹤0.05），miRNA -221적표체수평여갑상선유두상암조직적병리분급구유현저상관성（ r ＝0.823，P ﹤0.05）。결론miRNA -221재갑상선유두상암조직중표체교고，차여갑상선유두상암조직병리분급유상관성，miRNA -221재갑상선유두상암적발생여발전유중요작용。
Objective To explore the miRNA - 221 expression in thyroid neoplasms and its clinical pathological features. Methods Rt- PCR method was used to show the miRNA - 221 in thyroid papillary carcinoma tissues as well as the expression in normal thyroid tissue samples, and analyze the expression of miRNA - 221 and the correlation of clinical pathological features of thyroid papillary carcinoma. Results The results showed that the miRNA - 221 expression in thyroid papillary carcinoma tissue is significantly higher than normal thyroid tissue( P ﹤ 0. 05). The miRNA - 221 expression level was significantly associated with thyroid papillary carcinoma tissue pathology classification( r = 0. 823,P ﹤ 0. 05). Conclusion The miRNA - 221 showed high expression in thyroid papillary carcinoma tissues. The expression has correlation with thyroid papilla-ry carcinoma tissue pathology classification,which suggests that the miRNA - 221 play an important role in the occurrence and development of thy-roid papillary carcinoma.