CAJ | 학술논문

目的：研究尿和血胰岛素样生长因子-1（IGF -1）以及血清胱抑素 C（Cys C）水平变化在过敏性紫癜（HSP）和紫癜性肾炎（HSPN）中的意义。方法选取 HSP 患儿30例（HSP 组）、HSPN 患儿30例（HSPN 组）和健康儿童30例（对照组），分别采集尿和血，用化学发光法检测各组标本 IGF -1浓度；同时用全自动生化仪检测各组患儿血清Cys C、BUN、SCr 水平。结果①HSPN 组和 HSP 组尿和血 IGF -1的水平均高于对照组，差异均有统计学意义（ P ﹤0.05）。②HSP 组和 HSPN 组血清 Cys C 水平均高于对照组，差异有统计学意义（ P ﹤0.05）。③采用直线相关分析 HSPN组的血清 Cys C 水平与尿和血 IGF -1水平比较，存在正相关（ r ＝0.759、r ＝0.906，均 P ﹤0.05），尿 IGF -1与血 IGF -1水平也存在正相关（ r ＝0.661，P ﹤0.05）。结论 IGF -1为 HSPN 发病过程中促发因素，检测尿和血 IGF -1水平可作为过敏性紫癜早期肾损害的评价指标。
목적：연구뇨화혈이도소양생장인자-1（IGF -1）이급혈청광억소 C（Cys C）수평변화재과민성자전（HSP）화자전성신염（HSPN）중적의의。방법선취 HSP 환인30례（HSP 조）、HSPN 환인30례（HSPN 조）화건강인동30례（대조조），분별채집뇨화혈，용화학발광법검측각조표본 IGF -1농도；동시용전자동생화의검측각조환인혈청Cys C、BUN、SCr 수평。결과①HSPN 조화 HSP 조뇨화혈 IGF -1적수평균고우대조조，차이균유통계학의의（ P ﹤0.05）。②HSP 조화 HSPN 조혈청 Cys C 수평균고우대조조，차이유통계학의의（ P ﹤0.05）。③채용직선상관분석 HSPN조적혈청 Cys C 수평여뇨화혈 IGF -1수평비교，존재정상관（ r ＝0.759、r ＝0.906，균 P ﹤0.05），뇨 IGF -1여혈 IGF -1수평야존재정상관（ r ＝0.661，P ﹤0.05）。결론 IGF -1위 HSPN 발병과정중촉발인소，검측뇨화혈 IGF -1수평가작위과민성자전조기신손해적평개지표。
Objective To study the significance of urine and serum insulin - like growth factor 1(IGF - 1)and serum cystatin C(Cys C)levels in Henoch - Schonlein purpura(HSP)and Henoch - Schonlein purpura nephritis(HSPN). Methods Thirty HSP patients,25 HSPN patients and 30 healthy children(control group)were selected for the study. IGF - 1 concentration of specimens in each group was detected by chemiluminescence method;at the same time,the levels of serum BUN,SCr and Cys C were detected by automatic biochemistry analyzer. Results Urine and blood IGF - 1 levels in HSP group and HSPN group were significantly higher than the control group( P ﹤ 0. 05). Serum Cys C levels in HSP group and HSPN group were significantly higher than the control group( P ﹤ 0. 05). The linear correlation analysis showed that serum Cys C levels were positively correlated with urine and blood IGF - 1 levels in HSPN group( r = 0. 759 and r = 0. 906,respectively;all P ﹤ 0. 05);and the levels of urine IGF - 1 and blood IGF - 1 were positively correlated( r = 0. 661,P ﹤ 0. 05). Conclusion Urine and blood IGF - 1 can be used as the indicator for early renal damage in Henoch - Schoenlein purpura. The study suggests that IGF - 1 may promote the development of HSPN.