临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
Journal of Clinical and Experimental Medicine
2015年
20期
1695-1698
,共4页
饶进%殷莉%林志美%李世云%熊萍%苟小琴
饒進%慇莉%林誌美%李世雲%熊萍%茍小琴
요진%은리%림지미%리세운%웅평%구소금
多发性骨髓瘤%血红蛋白%平均血球血红蛋白%平均红细胞容积%红细胞分布宽度%胱抑素 C
多髮性骨髓瘤%血紅蛋白%平均血毬血紅蛋白%平均紅細胞容積%紅細胞分佈寬度%胱抑素 C
다발성골수류%혈홍단백%평균혈구혈홍단백%평균홍세포용적%홍세포분포관도%광억소 C
Multiple myeloma%Serum hemoglobin%The average blood hemoglobin concentration%The average volume of red blood cells%Red blood cell distribution width%Cystatin C
目的：探讨血液红系参数和胱抑素 C（CysC）联合检测在多发性骨髓瘤患者贫血病变程度判定中的价值。方法选取60例多发性骨髓瘤并贫血的初发住院患者，根据血红蛋白（HGB）水平不同分组，HGB≤60 g/ L 患者共21例（A 组），HGB 61~89 g/ L 患者23例（B 组），HGB 90~110 g/ L 患者16例（C 组）。分析各组血液红系参数平均血清血红蛋白（MCH）、平均血球血红蛋白浓度（MCHC）、平均红细胞容积（MCV）、红细胞分布宽度（RDW）及 CysC 水平，观察上述各指标与 HGB 的相关性。结果 A 组、B 组 HGB 低于 C 组，RDW、CysC 水平高于 C 组（ P ﹤0.05），A 组 HGB 低于B 组（ P ﹤0.05）；RDW、CysC 阳性率 A 组为85.71％、90.48％，B 组为78.26％、82.61％，C 组为25.00％、18.75％，A 组、B 组 RDW、CysC 阳性率高于 C 组阳性率（ P ﹤0.05）。患者 HGB 与 RDW、CysC 水平间 Pearson 相关性分析呈负相关（ P ﹤0.05）。结论对多发性骨髓瘤初发患者检测血液红系参数 RDW 及 CysC 有助于了解患者贫血病变程度变化，贫血改变与 RDW、CysC 升高关系密切。
目的：探討血液紅繫參數和胱抑素 C（CysC）聯閤檢測在多髮性骨髓瘤患者貧血病變程度判定中的價值。方法選取60例多髮性骨髓瘤併貧血的初髮住院患者，根據血紅蛋白（HGB）水平不同分組，HGB≤60 g/ L 患者共21例（A 組），HGB 61~89 g/ L 患者23例（B 組），HGB 90~110 g/ L 患者16例（C 組）。分析各組血液紅繫參數平均血清血紅蛋白（MCH）、平均血毬血紅蛋白濃度（MCHC）、平均紅細胞容積（MCV）、紅細胞分佈寬度（RDW）及 CysC 水平，觀察上述各指標與 HGB 的相關性。結果 A 組、B 組 HGB 低于 C 組，RDW、CysC 水平高于 C 組（ P ﹤0.05），A 組 HGB 低于B 組（ P ﹤0.05）；RDW、CysC 暘性率 A 組為85.71％、90.48％，B 組為78.26％、82.61％，C 組為25.00％、18.75％，A 組、B 組 RDW、CysC 暘性率高于 C 組暘性率（ P ﹤0.05）。患者 HGB 與 RDW、CysC 水平間 Pearson 相關性分析呈負相關（ P ﹤0.05）。結論對多髮性骨髓瘤初髮患者檢測血液紅繫參數 RDW 及 CysC 有助于瞭解患者貧血病變程度變化，貧血改變與 RDW、CysC 升高關繫密切。
목적：탐토혈액홍계삼수화광억소 C（CysC）연합검측재다발성골수류환자빈혈병변정도판정중적개치。방법선취60례다발성골수류병빈혈적초발주원환자，근거혈홍단백（HGB）수평불동분조，HGB≤60 g/ L 환자공21례（A 조），HGB 61~89 g/ L 환자23례（B 조），HGB 90~110 g/ L 환자16례（C 조）。분석각조혈액홍계삼수평균혈청혈홍단백（MCH）、평균혈구혈홍단백농도（MCHC）、평균홍세포용적（MCV）、홍세포분포관도（RDW）급 CysC 수평，관찰상술각지표여 HGB 적상관성。결과 A 조、B 조 HGB 저우 C 조，RDW、CysC 수평고우 C 조（ P ﹤0.05），A 조 HGB 저우B 조（ P ﹤0.05）；RDW、CysC 양성솔 A 조위85.71％、90.48％，B 조위78.26％、82.61％，C 조위25.00％、18.75％，A 조、B 조 RDW、CysC 양성솔고우 C 조양성솔（ P ﹤0.05）。환자 HGB 여 RDW、CysC 수평간 Pearson 상관성분석정부상관（ P ﹤0.05）。결론대다발성골수류초발환자검측혈액홍계삼수 RDW 급 CysC 유조우료해환자빈혈병변정도변화，빈혈개변여 RDW、CysC 승고관계밀절。
Objective To explore the combined detection of blood erythroid parameters and cystatin C(CysC)in observation of the severi-ty of anemia in patients with multiple myeloma,in order to provide the reference fordifferential diagnosis of multiple myeloma and severity of anemi-a. Methods A total of 60 cases of multiple myeloma and anemia in hospitalized patients were divided into 2 groups depending on the level of he-moglobin(HGB),21 patients with HGB 60 g/ L or less were allocated in group A,and 23 patients with HGB 61 ~ 89 g/ L in group B,16 patients with HGB 90 ~ 110 g/ L in group C,and the analysis of red blood cell parameters as MCH,MCHC,MCV,RDW and change in serum level of Cy-sC,observe the correlation of the respective index and HGB. Results The level of HGB in groups A and B waslower than that of group C,the lev-els of RDW and CysC in group A and group B were higher than those of group C( P ﹤ 0. 05),the level of HGB in group A was lower than that of group B( P ﹤ 0. 05);the positive rates of RDW andCysC in group A,group B and group C were 85. 71% and 90. 48% ,78. 26% and 82. 61% , 25. 00% and 18. 75% respectively. The positive rates of RDW and CysC in group A and group B were higher than those of group C( P ﹤ 0. 05);and Pearson correlation coefficient analysis on levels of RDW and CysC showed there was a negative correlation between them( P ﹤ 0. 05). Con-clusion In patients with incipient multiple myeloma,the measure of red blood parameters as RDW and change in level of CysC contributes to un-derstand the severity of anemia in patients with the degree of pathological changes,and the change in anemia is closely correlated with the increase of RDW andCysC.
