CAJ | 학술논문

目的：探讨轻度认知障碍（MCI）患者血清白蛋白和胆红素含量变化与认知损害之间的关系。方法：检测89例MCI组患者和82例对照组血清白蛋白、总胆红素、直接胆红素和间接胆红素水平；使用简易精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）对入选者进行神经心理学评价；比较两组间血清白蛋白和胆红素水平的变化，对MCI危险因素进行Logistic回归分析。结果：MCI组患者血清胆红素水平降低，差异有统计学意义（P＜0．05）；MCI组患者血清白蛋白水平下降，差异无统计学意义（P＞0．05）。血清胆红素水平与MMSE评分、MoCA总评分及子项目中注意、记忆、抽象得分呈正相关（P＜0．05），血清白蛋白水平与MMSE评分、MoCA评分之间无明显相关性（P＞0．05）；多因素Logistic回归分析显示：年龄、教育程度、糖尿病和血清胆红素水平是MCI独立危险因素。结论：MCI患者血清胆红素水平明显降低，与认知功能损害呈正相关。
목적：탐토경도인지장애（MCI）환자혈청백단백화담홍소함량변화여인지손해지간적관계。방법：검측89례MCI조환자화82례대조조혈청백단백、총담홍소、직접담홍소화간접담홍소수평；사용간역정신상태량표（MMSE）、몽특리이인지평고량표（MoCA）대입선자진행신경심이학평개；비교량조간혈청백단백화담홍소수평적변화，대MCI위험인소진행Logistic회귀분석。결과：MCI조환자혈청담홍소수평강저，차이유통계학의의（P＜0．05）；MCI조환자혈청백단백수평하강，차이무통계학의의（P＞0．05）。혈청담홍소수평여MMSE평분、MoCA총평분급자항목중주의、기억、추상득분정정상관（P＜0．05），혈청백단백수평여MMSE평분、MoCA평분지간무명현상관성（P＞0．05）；다인소Logistic회귀분석현시：년령、교육정도、당뇨병화혈청담홍소수평시MCI독립위험인소。결론：MCI환자혈청담홍소수평명현강저，여인지공능손해정정상관。
Objective To investigate the relationship between serum albumin, bilirubin and cognitive impairment in patients with mild cognitive impairment (MCI). Methods Serum albumin, total bilirubin, direct bilirubin, indirect bilirubin were analyzed in 89 cases of MCI and 82 cases of cognitively normal control. All of the cases underwent neuropsychological testing by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The risk factors of MCI were subject to Logistic regression analysis. Results The serum level of total bilirubin in MCI group were significantly lower than that in controls (P < 0.05). There was no significant difference in albumin between MCI and control group (P > 0.05). The bilirubin level was positively correlated with MMSE scores and MoCA scores (including attention, delayed recall and abstract) (P < 0.05), while no significant correlation between serum albumin level and scores of MMSE and MoCA (P > 0.05) by using Spearman correlation analysis. Logistic regression analysis showed that age, education level, diabetes and serum bilirubin levels were independent risk factors for MCI. Conclusion Our data show that decreased serum level of bilirubin is positively related to cognitive impairment.