岭南急诊医学杂志
嶺南急診醫學雜誌
령남급진의학잡지
Lingnan Journal of Emergency Medicine
2015年
5期
361-363
,共3页
包金兰%孙润陆%黄灿霞%张玉玲
包金蘭%孫潤陸%黃燦霞%張玉玲
포금란%손윤륙%황찬하%장옥령
HDL-P%HDL-C/P%早发冠心病%发病风险
HDL-P%HDL-C/P%早髮冠心病%髮病風險
HDL-P%HDL-C/P%조발관심병%발병풍험
HDL-P%HDL-C/P%premature coronary heart disease%risk factor
目的：探讨HDL－P、HDL－C／P与早发冠心病发病风险相关性。方法：搜集2012年1月－2015年7月在我院心内住院患者458例，男性＜55岁，女性＜65岁，其中冠心病组216例，对照组242例，均行冠状动脉造影，搜集临床资料；采用核磁共振光谱技术检测HDL－P数量，将HDL－P数量分为3组，大颗粒、中颗粒和小颗粒；按HDL－C／P 比值大小分为4组（HDL－C／P＜41．0组，41．0－46．9组，47．0－52．9组和≥53．0组）以SPPS18．0统计软件进行统计分析。结果：（1）采用多元logistic回归分析，校正吸烟、饮酒、高血压、糖尿病史等危险因素后，大颗粒HDL－P与小颗粒HDL－P相比较，显著降低冠心病发病风险OR（95％CI）为0．253（0．104－0．611，P＝0．002）；（2）与HDL－C／P比值≥53组相比较，HDL－C／P＜41组和41－46．9组均显著降低冠心病发病风险，OR（95％CI）分别为0．183（0．059－0．573），P≤0．01和0．295（0．099－0．883），P＜0．05。结论：HDL－P、HDL－C／P可能是评估早发冠心病发病风险的重要指标。
目的：探討HDL－P、HDL－C／P與早髮冠心病髮病風險相關性。方法：搜集2012年1月－2015年7月在我院心內住院患者458例，男性＜55歲，女性＜65歲，其中冠心病組216例，對照組242例，均行冠狀動脈造影，搜集臨床資料；採用覈磁共振光譜技術檢測HDL－P數量，將HDL－P數量分為3組，大顆粒、中顆粒和小顆粒；按HDL－C／P 比值大小分為4組（HDL－C／P＜41．0組，41．0－46．9組，47．0－52．9組和≥53．0組）以SPPS18．0統計軟件進行統計分析。結果：（1）採用多元logistic迴歸分析，校正吸煙、飲酒、高血壓、糖尿病史等危險因素後，大顆粒HDL－P與小顆粒HDL－P相比較，顯著降低冠心病髮病風險OR（95％CI）為0．253（0．104－0．611，P＝0．002）；（2）與HDL－C／P比值≥53組相比較，HDL－C／P＜41組和41－46．9組均顯著降低冠心病髮病風險，OR（95％CI）分彆為0．183（0．059－0．573），P≤0．01和0．295（0．099－0．883），P＜0．05。結論：HDL－P、HDL－C／P可能是評估早髮冠心病髮病風險的重要指標。
목적：탐토HDL－P、HDL－C／P여조발관심병발병풍험상관성。방법：수집2012년1월－2015년7월재아원심내주원환자458례，남성＜55세，녀성＜65세，기중관심병조216례，대조조242례，균행관상동맥조영，수집림상자료；채용핵자공진광보기술검측HDL－P수량，장HDL－P수량분위3조，대과립、중과립화소과립；안HDL－C／P 비치대소분위4조（HDL－C／P＜41．0조，41．0－46．9조，47．0－52．9조화≥53．0조）이SPPS18．0통계연건진행통계분석。결과：（1）채용다원logistic회귀분석，교정흡연、음주、고혈압、당뇨병사등위험인소후，대과립HDL－P여소과립HDL－P상비교，현저강저관심병발병풍험OR（95％CI）위0．253（0．104－0．611，P＝0．002）；（2）여HDL－C／P비치≥53조상비교，HDL－C／P＜41조화41－46．9조균현저강저관심병발병풍험，OR（95％CI）분별위0．183（0．059－0．573），P≤0．01화0．295（0．099－0．883），P＜0．05。결론：HDL－P、HDL－C／P가능시평고조발관심병발병풍험적중요지표。
Objective: To investigate the correlation between high density lipoprotein particle number (HDL-P), the ratio of high density lipoprotein cholesterol and HDL-P numbers (HDL-C/P) and risk factors in premature coronary heart disease (CHD). Methods: 458 patients (man<55,and female<65 years) were selected from cardiology department in our hospital from January 2012 to July 2015. All subjects were diagnosed by coronary angiography and divided into two groups: CHD group with 216 cases and Control group with 242 cases. HDL-P number were analyzed by nuclear magnetic resonance (NMR) spectroscopy and were classified into 3groups: Small, Medium and Large; the ratio of HDL-C/P were classified into 4 groups as below: <41.0, 41.0 to 46.9, 47.0 to 52.9, ≥53.0. Clinical data were collected and analyzed by SPSS 18.0. Results:(1) After adjusting the relative risk factors, which include smoking, drinking, hypertension, diabetes mellitus, large HDL-P could significantly decrease the risk of CHD than small HDL-P, the odds ratio (OR) and 95% CI were 0.253 (0.104-0.611),P=0.002; (2) Compared with HDL-C/P≥53 group, HDL-C/P<41 group and HDL-C/P 41 to 46.9 group significantly decreased the risk of CHD, OR and 95% CI were 0.183 (0.059-0.573), P<0.01 and 0.295 (0.099-0.883),P<0.05. Conclusion: HDL-P and HDL-C/P may be an important index for evaluating premature coronary heart disease.
