CAJ | 학술논문

目的：通过对结核性胸腔积液患者结核感染T细胞斑点试验（T-SPOT．TB）、胸腔积液腺苷脱氨酶（adenosine deaminase， ADA）、结核抗体（Tuberculosis antibody，TB-Ab）检测结果的对比，探讨T-SPOT．TB的临床诊断价值。方法：选取渗出性胸腔积液患者62例，根据诊断情况分为结核组32例，非结核组30例。入院后行T-SPOT．TB，TB-Ab，胸水ADA检验，将患者T-SPOT．TB检验结果与最终临床诊断进行对比，对其诊断的敏感性、特异性进行评价。结果：T-SPOT．TB、ADA、TB-Ab的敏感性分别为90．6％，71．9％，62．5％；特异性分别为：90．0％，83．3％，86．7％。 T-SPOT．TB敏感性高于其他两种检验方法，但进行统计学分析后， T-SPOT．TB与ADA敏感性比较差异无统计学意义（P ＞0．05），而与结核抗体敏感性比较差异有统计学意义（P ＜0．05）。结论：T-SPOT．TB对于结核性胸膜炎的诊断有着较高的敏感性和特异性，有助于结核性胸膜炎的早期诊断，与结核抗体联合检测有互补作用。
목적：통과대결핵성흉강적액환자결핵감염T세포반점시험（T-SPOT．TB）、흉강적액선감탈안매（adenosine deaminase， ADA）、결핵항체（Tuberculosis antibody，TB-Ab）검측결과적대비，탐토T-SPOT．TB적림상진단개치。방법：선취삼출성흉강적액환자62례，근거진단정황분위결핵조32례，비결핵조30례。입원후행T-SPOT．TB，TB-Ab，흉수ADA검험，장환자T-SPOT．TB검험결과여최종림상진단진행대비，대기진단적민감성、특이성진행평개。결과：T-SPOT．TB、ADA、TB-Ab적민감성분별위90．6％，71．9％，62．5％；특이성분별위：90．0％，83．3％，86．7％。 T-SPOT．TB민감성고우기타량충검험방법，단진행통계학분석후， T-SPOT．TB여ADA민감성비교차이무통계학의의（P ＞0．05），이여결핵항체민감성비교차이유통계학의의（P ＜0．05）。결론：T-SPOT．TB대우결핵성흉막염적진단유착교고적민감성화특이성，유조우결핵성흉막염적조기진단，여결핵항체연합검측유호보작용。
Objective To explore the value of T-SPOT.TB test in diagnosis of tuberculous pleurisy by comparing the T-SPOT.TB test, adenosine deaminase (ADA) of hydrothorax and tuberculosis antibody (TB-Ab). Methods 62 pleural effusion patients are included in the research , of which 32 cases have tuberculosis and 30 cases have no tuberculosis. All patients underwent T-SPOT.TB, pleural effusion ADA, and TB-Ab test. The results were compared with final clinical diagnosis for sensitivity and specificity evaluation. Results The sensitivity of T-SPOT.TB, ADA, TB-Ab were 90.6%, 71.9% and 62.5% respectively. The specificity of T-SPOT. TB, ADA, TB-Ab were 90.0%, 83.3% and 86.7% respectively. The sensitivity of T-SPOT.TB was the highest one among the three methods. The sensitivity of T-SPOT.TB has statistically significant difference compared with TB-Ab (P < 0.05), but no statistically significant difference compared with ADA (P > 0.05). Conclusions The T-SPOT.TB test had higher sensitivity and specificity for the diagnosis of tuberculous pleurisy , and had important reference value in early diagnosis of patients with tuberculous pleurisy. The T-SPOT.TB and TB-Ab combination examination had a complementary effect.