CAJ | 학술논문

目的：探索复合乳酸菌胶囊治疗慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）的价值。方法：100例AECOPD患者分为常规治疗组（对照组）50例和常规＋复合乳酸菌胶囊治疗组（治疗组）50例。记录2组住院天数、治疗前、治疗后7 d动脉血气、呼吸困难评分、肺功能、炎症指标、纳差评分、腹泻例数、真菌感染例数、死亡例数、呼吸频率和复合乳酸菌不良反应。结果：治疗后，治疗组和对照组血白细胞计数（white blood cell， WBC）分别为（7．4±2．0）×109／L和（8．8±2．6）×109／L（t ＝2．29，P ＝0．026）；治疗组和对照组中性粒细胞比例分别为（67±7）％和（73±13）％（t ＝2．09，P ＝0．042）；治疗组和对照组纳差评分≤2分的率分别为100％和84％（χ2＝6．66，P ＝0．010）。2组治疗后其余观察指标差异无显著性（P ＞0．05）。治疗组未见皮疹、腹泻等。结论：AECOPD患者口服复合乳酸菌胶囊有抗感染、改善食欲的作用，安全性好。
목적：탐색복합유산균효낭치료만성조새성폐질병급성가중기（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）적개치。방법：100례AECOPD환자분위상규치료조（대조조）50례화상규＋복합유산균효낭치료조（치료조）50례。기록2조주원천수、치료전、치료후7 d동맥혈기、호흡곤난평분、폐공능、염증지표、납차평분、복사례수、진균감염례수、사망례수、호흡빈솔화복합유산균불량반응。결과：치료후，치료조화대조조혈백세포계수（white blood cell， WBC）분별위（7．4±2．0）×109／L화（8．8±2．6）×109／L（t ＝2．29，P ＝0．026）；치료조화대조조중성립세포비례분별위（67±7）％화（73±13）％（t ＝2．09，P ＝0．042）；치료조화대조조납차평분≤2분적솔분별위100％화84％（χ2＝6．66，P ＝0．010）。2조치료후기여관찰지표차이무현저성（P ＞0．05）。치료조미견피진、복사등。결론：AECOPD환자구복복합유산균효낭유항감염、개선식욕적작용，안전성호。
Objective To observe the effects of lactobacillus complex capsules in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A hundred AECOPD patients were divided into 2 groups: the therapy group(n = 50) with conventional and lactobacillus complex capsules therapy, and the control group with conventional therapy only. Parameters before and after therapy were compared, which included length of hospital stay, arterial blood gases, dyspnea grade, respiratory function test, markers of inflammation, anorexia score, diarrhea, fungi infection, breathing rate, death rate and side-effects of lactobacillus complex capsules. Results After 7 days of treatment, the blood leukocyte count and neutrophil ratio in the therapy group were lower than that of the control group (P < 0.05). The rate of anorexia score ≤ 2 in the therapy group was higher than that of the control group (P < 0.05). There were no differences in the rest parameters among the two groups(P > 0.05). There were no side-effects, such as skin rash and diarrhea, to be observed in the therapy group. Conclusion Oral lactobacillus complex capsule can be safe, anti-infective and improve appetite in patients with AECOPD.