CAJ | 학술논문

背景：研究显示，在众多的种子细胞中滑膜间充质干细胞对关节软骨损伤再生修复具有许多独特的优势。目的：对滑膜间充质干细胞的研究进展及其关节腔内注射治疗关节软骨损伤的应用进行综述。<br>　　方法：第一作者通过计算机检索PubMed和CNKI数据库2004年1月至2014年12月的相关文献，检索关键词为“滑膜间充质干细胞、注射治疗、软骨修复；Synovial mesenchymal stem cel s；Intra-articular injection；Cartilage repair”，纳入57篇文献进行分析。<br>　　结果与结论：滑膜间充质干细胞分离培养方法简便，在软骨损伤修复方面具有很大的优势，通过将其注射于关节腔内治疗关节软骨损伤具有一定的可行性和安全性，作为一种潜在的治疗方式，有望给软骨损伤患者带来曙光，但仍然存在诸多问题，还需要进一步深入研究。
배경：연구현시，재음다적충자세포중활막간충질간세포대관절연골손상재생수복구유허다독특적우세。목적：대활막간충질간세포적연구진전급기관절강내주사치료관절연골손상적응용진행종술。<br>　　방법：제일작자통과계산궤검색PubMed화CNKI수거고2004년1월지2014년12월적상관문헌，검색관건사위“활막간충질간세포、주사치료、연골수복；Synovial mesenchymal stem cel s；Intra-articular injection；Cartilage repair”，납입57편문헌진행분석。<br>　　결과여결론：활막간충질간세포분리배양방법간편，재연골손상수복방면구유흔대적우세，통과장기주사우관절강내치료관절연골손상구유일정적가행성화안전성，작위일충잠재적치료방식，유망급연골손상환자대래서광，단잉연존재제다문제，환수요진일보심입연구。
BACKGROUND:Among various seed cel s, synovial mesenchymal stem cel s have unique advantages in the repair of articular cartilage injury. OBJECTIVE:To review the progress of synovial mesenchymal stem cel s and its intra-articular injection in the treatment of articular cartilage injury. METHODS:The first author searched PubMed and CNKI by computer to retrieve articles published from January 2004 to December 2004 using the keywords of“synovial mesenchymal stem cel s;intra-articular injection;cartilage repair”in English and Chinese, respectively. Final y, 57 articles were included in result analysis. RESULTS AND CONCLUSION:It is easy to isolate and culture synovial mesenchymal stem cel s, which has great advantages in cartilage repair. What’s more, intra-articular injection therapy for articular cartilage injury is feasible and safe. Intra-articular injection of synovial mesenchymal stem cel s is a very promising treatment for cartilage damage, but there are stil many problems to be solved in the future.