CAJ | 학술논문

自然转化是水平基因转化的一种基因编程机制，是细菌通过水平基因转移获得新的遗传信息的一种途径。DNA 处理蛋白 A(DNA processing protein A，DprA)是一种保守蛋白，它参与自然转化的多个环节，可以结合单链 DNA 并保护其免受核酸酶损伤；与重组酶 A 相互作用，利于重组酶 A 装载到裸露的单链 DNA 及被单链 DNA 结合蛋白覆盖的单链 DNA 上，随后进行染色体同源搜索及配对，可以减弱单链 DNA 结合蛋白的屏障作用，通过限制感受态刺激因子的早期基因表达，参与细胞感受态的关闭过程。本文对 DprA 蛋白在细菌自然转化中的作用进行综述。
자연전화시수평기인전화적일충기인편정궤제，시세균통과수평기인전이획득신적유전신식적일충도경。DNA 처리단백 A(DNA processing protein A，DprA)시일충보수단백，타삼여자연전화적다개배절，가이결합단련 DNA 병보호기면수핵산매손상；여중조매 A 상호작용，리우중조매 A 장재도라로적단련 DNA 급피단련 DNA 결합단백복개적단련 DNA 상，수후진행염색체동원수색급배대，가이감약단련 DNA 결합단백적병장작용，통과한제감수태자격인자적조기기인표체，삼여세포감수태적관폐과정。본문대 DprA 단백재세균자연전화중적작용진행종술。
Natural transformation is a genetically programmed mechanism of horizontal gene transfer in bacterial, which is a way for bacteria to obtain new genetic information. DNA processing protein A (DprA) is a conserved protein, which is involved in multiple aspects of natural transformation: DprA can bind and protect ssDNA, interact with RecA, promote the loading of RecA on ssDNA, alleviate the SSB barrier, and it also involves in the closing process of competent cells. In this article, the role of DprA in the natural transformation of bacteria is reviewed.