CAJ | 학술논문

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin，mTOR)是一种保守、非典型的丝氨酸/氨酸蛋白激酶，其主要通过复合体1(mTOR complex 1，mTORC1)和复合体2(mTOR complex 2，mTORC2)发挥作用。有研究证实，复合体1在心肌缺血期和再灌注期分别起到了不同的重要作用，通过调控复合体1可以影响细胞自噬水平、线粒体通透性转换孔的开放、抗氧化基因的上调等机制起到保护心肌的作用。本文对 mTOR 复合体的结构，以及 mTORC1信号分别在心肌缺血期和再灌注期的作用机制进行综述。
포유동물뢰파매소파단백(mammalian target of rapamycin，mTOR)시일충보수、비전형적사안산/안산단백격매，기주요통과복합체1(mTOR complex 1，mTORC1)화복합체2(mTOR complex 2，mTORC2)발휘작용。유연구증실，복합체1재심기결혈기화재관주기분별기도료불동적중요작용，통과조공복합체1가이영향세포자서수평、선립체통투성전환공적개방、항양화기인적상조등궤제기도보호심기적작용。본문대 mTOR 복합체적결구，이급 mTORC1신호분별재심기결혈기화재관주기적작용궤제진행종술。
The mammalian target of rapamycin (mTOR) is a conservative and atypical serine/threonine kinase which exerts its main functions through 2 different multi-protein complexes, named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) respectively. Recent studies have demonstrated that mTORC1 plays a pivotal cardioprotective role in phase of myocardial ischemia as well as reperfusion through modulating autophagy, activation of mitochondrial permeability transition pore (mPTP) and upregulation of antioxidant genes. This article reviews the structure of mTOR complexes and the pivotal role of mTORC1 signaling during the injury process of myocardial ischemia and reperfusion respectively.