CAJ | 학술논문

MicroRNA（ miRNA）的许多生物过程是通过影响靶基因的转录后表达。 miRNA与靶标之间的互补程度和性质决定其基因调控作用。结构相似性可以作为一个强有力的方法推断分子功能的相似性。然而，结构比对的方法来度量miRNA之间的相似性通常不太准确，而且时间开销大。对这些表达差异的miRNA的靶标基因进行聚类，可以很好地理解miRNA的功能。提出一个新的GO（ gene Ontology）语义相似性的方法来区分miR-NA功能组。该方法采用项信息和边的权重来度量GO项的权重。此外，2个GO图的共同项和非共同项还被用来度量这2个图之间的相似度。对于2个miRNA，它们之间的相似性可以用它们靶标基因标注的GO项的相似性来计算。实验结果表明此方法不仅可以将相似功能的miRNA聚在一起，而且可以预测未知miRNA的功能。
MicroRNA（ miRNA）적허다생물과정시통과영향파기인적전록후표체。 miRNA여파표지간적호보정도화성질결정기기인조공작용。결구상사성가이작위일개강유력적방법추단분자공능적상사성。연이，결구비대적방법래도량miRNA지간적상사성통상불태준학，이차시간개소대。대저사표체차이적miRNA적파표기인진행취류，가이흔호지리해miRNA적공능。제출일개신적GO（ gene Ontology）어의상사성적방법래구분miR-NA공능조。해방법채용항신식화변적권중래도량GO항적권중。차외，2개GO도적공동항화비공동항환피용래도량저2개도지간적상사도。대우2개miRNA，타문지간적상사성가이용타문파표기인표주적GO항적상사성래계산。실험결과표명차방법불부가이장상사공능적miRNA취재일기，이차가이예측미지miRNA적공능。
A lot of biological processes of MicroRNA( miRNA)functions are expressed by affecting the post transcriptional target genes. The complementary degree and nature between the miRNA and target can determine its gene-regulatory roles. The structure similarity infers a powerful clue in similarity of molecular function. How-ever ,the structural alignment for measuring similarity of miRNAs is subject to distance metric and is usually com-putationally intensive. To classify the function of those target genes of differentially expressed miRNAs offers a better understanding of the function of miRNAs. This paper proposes a novel GO( gene ontology)semantic simi-larity method to divide function group of miRNAs. We exploit the information content and depth to evaluate the weight of GO terms. Furthermore,the common and uncommon terms are adopted to measure similarities between two GO graphs. As to two miRNAs,their function similarity is calculated by GO terms similarity of associated tar-get genes. The results show that this method can not only cluster similar function of miRNAs into the same group, but also predict the functions of miRNAs.