CAJ | 학술논문

微小RNA（miRNA）是一类非编码小RNA ，长度为18～25个核苷酸，可结合mRNA的3′非翻译区，发挥着重要的转录后调控作用。miRNA涉及人类多种疾病的形成，因此迅速成为疾病诊断、预后评价的新一代生物标记及新型治疗靶点。在人类免疫缺陷病毒（HIV）／获得性免疫缺陷综合征（AIDS）的疾病进展过程中，宿主miRNA可能通过直接干预病毒复制或免疫应答而影响宿主的临床转归。本文主要综述宿主miRNA作为HIV‐1感染疾病进展预测标记和抗病毒治疗潜在靶标的研究进展。
미소RNA（miRNA）시일류비편마소RNA ，장도위18～25개핵감산，가결합mRNA적3′비번역구，발휘착중요적전록후조공작용。miRNA섭급인류다충질병적형성，인차신속성위질병진단、예후평개적신일대생물표기급신형치료파점。재인류면역결함병독（HIV）／획득성면역결함종합정（AIDS）적질병진전과정중，숙주miRNA가능통과직접간예병독복제혹면역응답이영향숙주적림상전귀。본문주요종술숙주miRNA작위HIV‐1감염질병진전예측표기화항병독치료잠재파표적연구진전。
microRNA (miRNA ) is a class of small non‐coding RNA with the length of 18‐25 nucleotides , which plays an important role in regulating posttranscriptional level gene expression through binding to 3′‐untranslated region (UTR) of mRNA .Given its involvement in the development of various human diseases , miRNAs are emerging as a new generation biomarkers for diagnosis and prognosis , as well as novel therapeutic targets . The disease progression of human immunodeficiency virus ( HIV )/acquired immunodeficiency syndrome (AIDS) might be modified by miRNA through the regulation of viral replication or host immune responses induced by HIV‐1 infection .Here ,the progresses on host miRNAs as potential biomarkers for disease progression in HIV‐1 infection ,as well as potential targets for antiretroviral therapy are reviewed in the present paper .