CAJ | 학술논문

迄今为止，获得性免疫缺陷综合征（AIDS）在全球仍是非常严重的传染病，没有彻底治愈的疗法。抗病毒疗法可抑制人类免疫缺陷病毒（HIV）复制，但不能彻底清除潜藏在人基因组中的 HIV基因组序列。最近，基因组编辑技术如锌指核酸酶（ZFN）技术、类转录激活因子效应物核酸酶（TALEN）技术和成簇的规律间隔的短回文重复序列及其相关蛋白（CRISPR‐Cas）技术被发现可成功破坏整合在人基因组中的 HIV基因组序列，并成功诱导HIV辅助受体C‐C趋化因子受体5（CCR5）缺失突变，而这种突变可抵抗 HIV进入细胞。基因组编辑技术的成功应用将为治愈AIDS带来曙光。
흘금위지，획득성면역결함종합정（AIDS）재전구잉시비상엄중적전염병，몰유철저치유적요법。항병독요법가억제인류면역결함병독（HIV）복제，단불능철저청제잠장재인기인조중적 HIV기인조서렬。최근，기인조편집기술여자지핵산매（ZFN）기술、류전록격활인자효응물핵산매（TALEN）기술화성족적규률간격적단회문중복서렬급기상관단백（CRISPR‐Cas）기술피발현가성공파배정합재인기인조중적 HIV기인조서렬，병성공유도HIV보조수체C‐C추화인자수체5（CCR5）결실돌변，이저충돌변가저항 HIV진입세포。기인조편집기술적성공응용장위치유AIDS대래서광。
Acquired immunodeficiency syndrome (AIDS ) , still a serious infectious disease , causes global epidemic and remains incurable until now .The current available antiretroviral therapy successfully inhibits human immunodeficiency virus (HIV ) replication , but cannot eradicate the genome‐integrated HIV . Recently ,genome editing techniques ,such as zinc finger nucleases (ZFNs) , transcription activator‐like effectors nucleases (TALENs) ,clustered regularly interspaced short palindromic repeats (CRISPR ) and CRISPR‐associated proteins (Cas) (CRISPR/Cas system) , have been found to successfully disrupt the integrated HIV‐1 genes . Furthermore , genome editing techniques also have successfully induced C‐C chemokine receptor type 5 ( CCR5 ) Δ32 mutation , a mutation of HIV entry co‐receptor CCR5 that is resistant to HIV infection . Therefore , genome editing techniques bring the glimmers of success in eradication of HIV in human bodies .