CAJ | 학술논문

目的探讨路易体痴呆(DLB)患者的睡眠结构特点及其认知受损程度与睡眠结构的关系.方法对临床诊断DLB患者34例行多导睡眠监测,用简易智能精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、临床痴呆评定量表(CDR)评定患者的认知功能.结果 (1)睡眠结构分析:与正常对照组相比,DLB组总睡眠间期时间(SPT)减少(P＜0.05);总睡眠时间(TST)减少,睡眠效率(SE)下降,总醒觉时间(TWT)、入睡后清醒时间(WASO)增多,1期睡眠时间(TS1)、2期睡眠时间(TS2)、非快动眼(NREM)睡眠时间(TNREMS)和快动眼(REM)睡眠时间(TREMS)均明显减少(均P ＜0.01);(2)根据MMSE、MoCA、CDR评分结果将DLB组患者分组,组间的睡眠结构比较差异无统计学意义(均P ＞0.05).结论 DLB患者存在睡眠结构紊乱,DLB患者的认知受损程度与睡眠结构改变无明显相关,提示与其他神经变性疾病引起的痴呆不同.
목적 탐토로역체치태(DLB)환자적수면결구특점급기인지수손정도여수면결구적관계.방법 대림상진단DLB환자34례행다도수면감측,용간역지능정신상태량표(MMSE)、몽특리이인지평고량표(MoCA)、림상치태평정량표(CDR)평정환자적인지공능.결과 (1)수면결구분석:여정상대조조상비,DLB조총수면간기시간(SPT)감소(P＜0.05);총수면시간(TST)감소,수면효솔(SE)하강,총성각시간(TWT)、입수후청성시간(WASO)증다,1기수면시간(TS1)、2기수면시간(TS2)、비쾌동안(NREM)수면시간(TNREMS)화쾌동안(REM)수면시간(TREMS)균명현감소(균P ＜0.01);(2)근거MMSE、MoCA、CDR평분결과장DLB조환자분조,조간적수면결구비교차이무통계학의의(균P ＞0.05).결론 DLB환자존재수면결구문란,DLB환자적인지수손정도여수면결구개변무명현상관,제시여기타신경변성질병인기적치태불동.
Objective To investigate the sleep architecture in dementia with Lewy bodies (DLB),and study the sleep architecture and cognitive functions in DLB.Methods We described polysomnography (PSG) findings in 34 consecutive subjects diagnosed with DLB.All the patients underwent Mini-Mental State Examination (MMSE),Montreal Cognitive Assessment (MoCA),Clinical Dementia Rating (CDR) to quantify cognitive functions.Results (1)Sleep architecture analysis:DLB group compared to normal control group,the sleep period time (SPT) was reduced (P ＜ 0.05),total sleep time (TST) and sleep efficiency (SE) were decreased,total wake time (TWT) and wake after sleep onset (WASO) were increased,1 non-rapid eye movement (NREM) sleep (TS1),2NREM sleep (TS2),total NREM sleep (TNREMS),and REM sleep (TREMS) time were significantly decreased (P ＜0.01).(2)The DLB patients were divided into groups based on MMSE,MoCA,qnd CDR scores,the sleep architecture of each group was no significant difference (P ＞ 0.05).Conclusions Patients with DLB exists sleep architecture disorder.The cognitive functions and sleep architecture changes in patients with DLB have no obvious correlation.It is different from other degenerative dementia.