CAJ | 학술논문

目的：研究血细胞比容及碱剩余评估特重烧伤患者休克复苏效果的临床价值。方法将2012年4月至2014年6月期间就诊的40例特重度烧伤伴休克患者纳入研究对象，入院后接受液体复苏治疗，根据复苏后1 d 和2 d时血细胞比容以及碱剩余情况不同分为正常组和异常组。采用酶联免疫吸附法检测白细胞介素4（IL -4）和白细胞介素6（IL -6）、肿瘤坏死因子（TNF -α）。结果复苏后1 d 和2 d 时，血细胞比容正常组不同时点血比容均明显低于异常组，IL -4、IL -6、TNF -α含量均低于血细胞比容异常组；碱剩余正常组不同时点碱剩余含量均明显高于对照组，IL -4、IL -6、TNF -α含量均低于碱剩余异常组。结论血细胞比容越低、碱剩余越高，特重烧伤患者休克复苏后的炎症反应越弱、复苏效果越好；血细胞比容及碱剩余是评估复苏效果的理想指标。
목적：연구혈세포비용급감잉여평고특중소상환자휴극복소효과적림상개치。방법장2012년4월지2014년6월기간취진적40례특중도소상반휴극환자납입연구대상，입원후접수액체복소치료，근거복소후1 d 화2 d시혈세포비용이급감잉여정황불동분위정상조화이상조。채용매련면역흡부법검측백세포개소4（IL -4）화백세포개소6（IL -6）、종류배사인자（TNF -α）。결과복소후1 d 화2 d 시，혈세포비용정상조불동시점혈비용균명현저우이상조，IL -4、IL -6、TNF -α함량균저우혈세포비용이상조；감잉여정상조불동시점감잉여함량균명현고우대조조，IL -4、IL -6、TNF -α함량균저우감잉여이상조。결론혈세포비용월저、감잉여월고，특중소상환자휴극복소후적염증반응월약、복소효과월호；혈세포비용급감잉여시평고복소효과적이상지표。
Objective To study the clinical significance of hematocrit and alkaline excess in evaluating resuscitation effect of shock in pa-tients with severe burn. Methods A total of 40 patients with severe burn complicated with shock in this hospital during April 2012 to June 2014 were enrolled in this study and fluid had been given to them for resuscitation. These patients were divided into two groups according to hematocrit and alkaline excess at 1 d and 3 d after fluid resuscitation. Serum levels of interleukin - 4(IL - 4),IL - 6 and tumor necrosis factor - α(TNF -α)were detected by enzyme - linked immunosorbent assay(ELISA). Results After fluid restoration for 1d and 2 days,hematocrit in normal group at different time point was significantly lower than that of abnormal group,serum levels of IL - 4,IL - 6 and TNF - α were significantly low-er than those of abnormal group;alkaline excess in normal group at different time point was significantly higher than those of abnormal group,ser-um levels of IL - 4,IL - 6 and TNF - α were significantly lower than those of abnormal group. Conclusion As hematocrit gets lower and alkaline excess gets higher,the inflammatory reaction in patients with severe burn is weaker and resuscitation effect is better;hematocrit and alkaline excess are ideal indexes for evaluating resuscitation effect of shock in patients with severe burn.