心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
Chinese Journal of Cardiovascular Rehabilitation Medicine
2015年
5期
471-475
,共5页
李玉%段敬柱%王崇全%陈相健
李玉%段敬柱%王崇全%陳相健
리옥%단경주%왕숭전%진상건
糖尿病 ,2型%高血压%抵抗素
糖尿病 ,2型%高血壓%牴抗素
당뇨병 ,2형%고혈압%저항소
Diabetes mellitus,type 2%Hypertension%Resistin
目的：研究血清抵抗素（SR）水平与2型糖尿病（T2DM）合并高血压患者血压的相关性。方法：选择T2DM合并高血压患者（T2DM合并高血压组）124例，单纯T2DM患者（单纯糖尿病组）85例，正常对象（正常对照组）71例纳入研究。根据血压水平，T2DM合并高血压组被进一步分为1级亚组（34例），2级亚组（43例）和3级亚组（47例）。取外周静脉血测量三组SR及其他指标水平。Logistic多元回归分析用来分析影响血压水平的危险因素。Kendall′s tau‐b相关分析用来分析SR ，空腹胰岛素，量化胰岛素敏感指数和胰岛素抵抗指数与血压水平的相关性。结果：与健康对照组比较，单纯糖尿病组和T2DM合并高血压组SR水平显著升高[（7.21±2.65） ng／ml比（19.87±3.67） ng／ml比（31.32±3.89） ng／ml]，且T2DM合并高血压组的显著高于单纯糖尿病组的（P均＜0.01）。Logistic多元回归分析表明SR水平是影响患者血压水平的独立危险因素（R2＝0.087， P＜0.05）。Kendall′s tau‐b相关分析显示SR水平与高血压患者血压水平呈显著正相关（ r＝0.202， P＝0.001）；控制其余影响因素后，二者间仍然呈显著正相关（ r＝0.233， P＝0.022）。结论：血清抵抗素水平是2型糖尿病合并高血压患者的危险因素，与其血压水平呈显著正相关。
目的：研究血清牴抗素（SR）水平與2型糖尿病（T2DM）閤併高血壓患者血壓的相關性。方法：選擇T2DM閤併高血壓患者（T2DM閤併高血壓組）124例，單純T2DM患者（單純糖尿病組）85例，正常對象（正常對照組）71例納入研究。根據血壓水平，T2DM閤併高血壓組被進一步分為1級亞組（34例），2級亞組（43例）和3級亞組（47例）。取外週靜脈血測量三組SR及其他指標水平。Logistic多元迴歸分析用來分析影響血壓水平的危險因素。Kendall′s tau‐b相關分析用來分析SR ，空腹胰島素，量化胰島素敏感指數和胰島素牴抗指數與血壓水平的相關性。結果：與健康對照組比較，單純糖尿病組和T2DM閤併高血壓組SR水平顯著升高[（7.21±2.65） ng／ml比（19.87±3.67） ng／ml比（31.32±3.89） ng／ml]，且T2DM閤併高血壓組的顯著高于單純糖尿病組的（P均＜0.01）。Logistic多元迴歸分析錶明SR水平是影響患者血壓水平的獨立危險因素（R2＝0.087， P＜0.05）。Kendall′s tau‐b相關分析顯示SR水平與高血壓患者血壓水平呈顯著正相關（ r＝0.202， P＝0.001）；控製其餘影響因素後，二者間仍然呈顯著正相關（ r＝0.233， P＝0.022）。結論：血清牴抗素水平是2型糖尿病閤併高血壓患者的危險因素，與其血壓水平呈顯著正相關。
목적：연구혈청저항소（SR）수평여2형당뇨병（T2DM）합병고혈압환자혈압적상관성。방법：선택T2DM합병고혈압환자（T2DM합병고혈압조）124례，단순T2DM환자（단순당뇨병조）85례，정상대상（정상대조조）71례납입연구。근거혈압수평，T2DM합병고혈압조피진일보분위1급아조（34례），2급아조（43례）화3급아조（47례）。취외주정맥혈측량삼조SR급기타지표수평。Logistic다원회귀분석용래분석영향혈압수평적위험인소。Kendall′s tau‐b상관분석용래분석SR ，공복이도소，양화이도소민감지수화이도소저항지수여혈압수평적상관성。결과：여건강대조조비교，단순당뇨병조화T2DM합병고혈압조SR수평현저승고[（7.21±2.65） ng／ml비（19.87±3.67） ng／ml비（31.32±3.89） ng／ml]，차T2DM합병고혈압조적현저고우단순당뇨병조적（P균＜0.01）。Logistic다원회귀분석표명SR수평시영향환자혈압수평적독립위험인소（R2＝0.087， P＜0.05）。Kendall′s tau‐b상관분석현시SR수평여고혈압환자혈압수평정현저정상관（ r＝0.202， P＝0.001）；공제기여영향인소후，이자간잉연정현저정상관（ r＝0.233， P＝0.022）。결론：혈청저항소수평시2형당뇨병합병고혈압환자적위험인소，여기혈압수평정현저정상관。
Objective:To study the correlation between serum resistin (SR) level and blood pressure in patients with type 2 diabetes mellitus (T2DM) complicated hypertension .Methods :A total of 124 patients with T2DM complicat‐ed hypertension (T2DM + hypertension group) ,85 patients with pure T2DM (pure DM group) and 71 normal sub‐jects (normal control group) were enrolled .According to blood pressure level ,T2DM + hypertension group was further divided into stage 1 subgroup (n=34) ,stage 2 subgroup (n=43) and stage 3 subgroup (n=47) .Peripheral venous blood was taken to measure levels of SR and other indexes in three groups .Logistic multi‐factor regression a‐nalysis was used to analyze the risk factors affecting blood pressure level .Kendall's tau‐b correlation analysis was used to analyze the correlation among SR ,fasting insulin ,quantitative insulin sensitivity check index ,homeostasis model‐insulin resistance index and blood pressure level .Results:Compared with normal control group ,there were significant rise in SR levels [ (7.21 ± 2.65) ng/ml vs .(19.87 ± 3.67) ng/ml vs .(31.32 ± 3.89) ng/ml] in pure DM group and T2DM + hypertension group ,and that of T2DM + hypertension group was significantly higher than that of pure DM group , P<0.01 all .Logistic multi‐factor regression analysis indicated that SR level was an independent risk factor influencing blood pressure level of patients (R2 =0.087 , P<0.05) .Kendall's tau‐b correlation analysis indicated that SR level was significantly positively correlated with blood pressure level of patients with hypertension (r=0.202 ,P=0.001);after other influencing factors were controlled ,the significant positive correlation still exis‐ted between them ( r=0.233 , P=0.022) .Conclusion:Serum resistin level rise is risk factor of patients with type 2 diabetes mellitus complicated hypertension ,and it significantly positively correlated with their blood pressure level .
