中医临床研究
中醫臨床研究
중의림상연구
Clinical Journal of Chinese Medicine
2015年
25期
7-10
,共4页
白春颖%姜彩霞%李明%张晶
白春穎%薑綵霞%李明%張晶
백춘영%강채하%리명%장정
附芪强心汤%慢性心力衰竭%阳虚血瘀
附芪彊心湯%慢性心力衰竭%暘虛血瘀
부기강심탕%만성심력쇠갈%양허혈어
The Fuqi Qiangxin decoction%Chronic heart failure%Yangxu Xueyu
目的：观察附芪强心汤治疗慢性心力衰竭（阳虚血瘀证）的临床疗效。方法：将符合入选标准的心衰患者68例随机分为治疗组、对照组各34例，对照组给予西医常规治疗（休息，控钠，吸氧，并予利尿剂、β-受体阻滞剂、血管转化酶抑制剂、强心类药物、硝酸酯类药物）；治疗组在对照组的基础上，加服附芪强心汤150mL，2次/d，口服。两组疗程均为3周。分别于治疗前后观察血浆脑钠肽（BNP）、心电图、肝肾功能、心功能（NYHA）分级、中医证候疗效评分、左室射血分数（LVEF）、左室舒张末期内径（LVEDD）、每分钟搏出量（CO）等。结果：治疗组的中医证候疗效评分总有效率优于对照组，P<0.05，差异具有统计学意义；治疗组的心功能改善总有效率优于对照组，P<0.05，差异具有统计学意义。治疗组治疗后血浆BNP水平明显降低，左室舒张末期内径（LVEDD）明显缩小，左室射血分数（LVEF）及每分钟搏出量（CO）明显提高，与治疗前及对照组相比， P<0.05，差异具有统计学意义。结论：附芪强心汤能够降低血浆BNP水平，缩小LVEDD，提高LVEF及CO，增强心肌收缩力及改善心功能。
目的：觀察附芪彊心湯治療慢性心力衰竭（暘虛血瘀證）的臨床療效。方法：將符閤入選標準的心衰患者68例隨機分為治療組、對照組各34例，對照組給予西醫常規治療（休息，控鈉，吸氧，併予利尿劑、β-受體阻滯劑、血管轉化酶抑製劑、彊心類藥物、硝痠酯類藥物）；治療組在對照組的基礎上，加服附芪彊心湯150mL，2次/d，口服。兩組療程均為3週。分彆于治療前後觀察血漿腦鈉肽（BNP）、心電圖、肝腎功能、心功能（NYHA）分級、中醫證候療效評分、左室射血分數（LVEF）、左室舒張末期內徑（LVEDD）、每分鐘搏齣量（CO）等。結果：治療組的中醫證候療效評分總有效率優于對照組，P<0.05，差異具有統計學意義；治療組的心功能改善總有效率優于對照組，P<0.05，差異具有統計學意義。治療組治療後血漿BNP水平明顯降低，左室舒張末期內徑（LVEDD）明顯縮小，左室射血分數（LVEF）及每分鐘搏齣量（CO）明顯提高，與治療前及對照組相比， P<0.05，差異具有統計學意義。結論：附芪彊心湯能夠降低血漿BNP水平，縮小LVEDD，提高LVEF及CO，增彊心肌收縮力及改善心功能。
목적：관찰부기강심탕치료만성심력쇠갈（양허혈어증）적림상료효。방법：장부합입선표준적심쇠환자68례수궤분위치료조、대조조각34례，대조조급여서의상규치료（휴식，공납，흡양，병여이뇨제、β-수체조체제、혈관전화매억제제、강심류약물、초산지류약물）；치료조재대조조적기출상，가복부기강심탕150mL，2차/d，구복。량조료정균위3주。분별우치료전후관찰혈장뇌납태（BNP）、심전도、간신공능、심공능（NYHA）분급、중의증후료효평분、좌실사혈분수（LVEF）、좌실서장말기내경（LVEDD）、매분종박출량（CO）등。결과：치료조적중의증후료효평분총유효솔우우대조조，P<0.05，차이구유통계학의의；치료조적심공능개선총유효솔우우대조조，P<0.05，차이구유통계학의의。치료조치료후혈장BNP수평명현강저，좌실서장말기내경（LVEDD）명현축소，좌실사혈분수（LVEF）급매분종박출량（CO）명현제고，여치료전급대조조상비， P<0.05，차이구유통계학의의。결론：부기강심탕능구강저혈장BNP수평，축소LVEDD，제고LVEF급CO，증강심기수축력급개선심공능。
Objective:To observe clinical efficacy of the Fuqi Qiangxin decoction on chronic heart failure. Methods:68 cases of chronic heart failure were randomly divided into the treatment group (34 cases) and the control group (34 cases). The control group was treated by routine treatment (rest, sodium, oxygen, and diuretics, beta blockers, ACE inhibitors, strong heart drugs, nitrates).The treatment group was treated with 150mL of the Fuqi Qiangxin decoction more, 2 times per day, for 3 weeks. BNP, electrocardiogram, liver and kidney function, cardiac function, NYHA, LVEF, LVEDD, and CO were observed before and after treatment. Results:The total efficiency of TCM symptom score in the treatment group was better than that in the control group, P<0.05. The total efficiency of heart function improved in the treatment group was better than that in the control group, P<0.05. After treatment, the plasma BNP level was significantly decreased. LVEDD was significantly reduced. LVEF and CO were significantly improved. The difference between two groups was statistically significant. Conclusion:The Fuqi Qiangxin decoction can reduce the plasma BNP level, reduce LVEDD, improve LVEF and CO, and enhance myocardial contractility and improve heart function.
