中国医师杂志
中國醫師雜誌
중국의사잡지
Journal of Chinese Physician
2015年
9期
1320-1324
,共5页
禹虹%高士友%唐慧珍%陈辉莲%邓朝晖%阳翎%柳朝华%汤倩倩%唐亭亭
禹虹%高士友%唐慧珍%陳輝蓮%鄧朝暉%暘翎%柳朝華%湯倩倩%唐亭亭
우홍%고사우%당혜진%진휘련%산조휘%양령%류조화%탕천천%당정정
子宫疾病/药物疗法%生长激素/投药和剂量%输注,胃肠外%激素替代疗法%胚胎移植
子宮疾病/藥物療法%生長激素/投藥和劑量%輸註,胃腸外%激素替代療法%胚胎移植
자궁질병/약물요법%생장격소/투약화제량%수주,위장외%격소체대요법%배태이식
Uterine diseases/DT%Growth hormone/AD%Infusions,parenteral%Hormone replacement therapy%Embryo transfer
目的 探讨生长激素(GH)宫腔灌注联合激素替代周期(HRT)在冻融胚胎移植(FET)中治疗无反应型薄型子宫内膜的疗效.方法 前瞻性选择2014年6月至12月湖南省妇幼保健院生殖中心行FET且无反应性薄型子宫内膜患者5例,应用GH宫腔灌注联合HRT进行FET.结果 5例患者在HRT备膜基础上均接受4～5次GH宫腔灌注治疗,与自身比较,GH宫腔灌注后黄体酮日子宫内膜厚度[(7.96 ±0.71)mm]显著大于首次灌注子宫内膜厚度[(5.78 ±0.65) mm],增加其厚度(2.18 ±0.47)mm,其差异有统计学意义(t=10.46,P＜0.01);其移植日子宫内膜厚度均＞7mm.5例患者获得临床妊娠,胚胎种植率72.73％(8/11).结论 GH宫腔灌注联合HRT在FET中治疗无反应性薄型子宫内膜有一定疗效,既可增加其子宫内膜厚度,又能改善内膜容受性,有利于提高冻胚种植率和临床妊娠率.
目的 探討生長激素(GH)宮腔灌註聯閤激素替代週期(HRT)在凍融胚胎移植(FET)中治療無反應型薄型子宮內膜的療效.方法 前瞻性選擇2014年6月至12月湖南省婦幼保健院生殖中心行FET且無反應性薄型子宮內膜患者5例,應用GH宮腔灌註聯閤HRT進行FET.結果 5例患者在HRT備膜基礎上均接受4～5次GH宮腔灌註治療,與自身比較,GH宮腔灌註後黃體酮日子宮內膜厚度[(7.96 ±0.71)mm]顯著大于首次灌註子宮內膜厚度[(5.78 ±0.65) mm],增加其厚度(2.18 ±0.47)mm,其差異有統計學意義(t=10.46,P＜0.01);其移植日子宮內膜厚度均＞7mm.5例患者穫得臨床妊娠,胚胎種植率72.73％(8/11).結論 GH宮腔灌註聯閤HRT在FET中治療無反應性薄型子宮內膜有一定療效,既可增加其子宮內膜厚度,又能改善內膜容受性,有利于提高凍胚種植率和臨床妊娠率.
목적 탐토생장격소(GH)궁강관주연합격소체대주기(HRT)재동융배태이식(FET)중치료무반응형박형자궁내막적료효.방법 전첨성선택2014년6월지12월호남성부유보건원생식중심행FET차무반응성박형자궁내막환자5례,응용GH궁강관주연합HRT진행FET.결과 5례환자재HRT비막기출상균접수4～5차GH궁강관주치료,여자신비교,GH궁강관주후황체동일자궁내막후도[(7.96 ±0.71)mm]현저대우수차관주자궁내막후도[(5.78 ±0.65) mm],증가기후도(2.18 ±0.47)mm,기차이유통계학의의(t=10.46,P＜0.01);기이식일자궁내막후도균＞7mm.5례환자획득림상임신,배태충식솔72.73％(8/11).결론 GH궁강관주연합HRT재FET중치료무반응성박형자궁내막유일정료효,기가증가기자궁내막후도,우능개선내막용수성,유리우제고동배충식솔화림상임신솔.
Objective To assess the efficacy of growth hormone(GH) intrauterine administration combined with hormone replacement cycle (HRT) in frozen-thawed embryo transfer (FET) cycles for unresponsive thin endometrium.Methods Prospective cohort study of five consecutive women undergoing invitro fertilization (IVF) who,after standard endometrial preparation,still demonstrated highly inadequate endometrium.They all accepted transvaginal endometrial perfusion with GH in FET cycles.Results Five patients with unresponsive thin endometrium accepted four or five GH intrauterine administrations during FET cycles.The average endometrial expansion at endometrial conversion date was (2.18 ±0.47) mm,from (5.78 ±0.65) mm to (7.96 ±0.71) mm.Successful endometrial expansion to at least minimal thickness of 7 mm after uterine perfusion with GH in five patients previously resistant to treatment with estrogen.All five patients therefore reached FET,and all five also conceived,and embryo implantation rate was 72.73％ (8/11).Conclusions Uterine perfusion with GH combined with HRT represents a promising new treatment for the unresponsive thin endometrium patients in FET.This treatment also deserves further investigation for its potential to improve implantation chances in association with assisted reproduction.
