心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
Chinese Journal of Cardiovascular Rehabilitation Medicine
2015年
5期
536-539
,共4页
急性冠状动脉综合征%利钠肽 ,脑%非诺贝特
急性冠狀動脈綜閤徵%利鈉肽 ,腦%非諾貝特
급성관상동맥종합정%리납태 ,뇌%비낙패특
Acute coronary syndrome%Natriuretic peptide,brain%Fenofibrate
目的:探讨非诺贝特对老年急性冠脉综合征(ACS)患者血浆脑钠肽(BNP)及心率变异性(HRV)的影响。方法:选择我院的ACS老年患者150例,随机分成常规治疗组和非诺贝特组(常规治疗联合非诺贝特治疗),各75例。对比治疗前后患者血浆BNP水平、 HRV参数、血脂水平和胸痛的变化。结果:治疗后,两组 BNP , HRV和血脂水平均明显改善(P均<0.01);与常规治疗组比较,非诺贝特组血浆BNP水平[(132.5±22.1) pg/ml比(91.2±13.7) pg/ml]降低更显著(P<0.01), HRV中正常窦性R‐R间期总体标准差(SDNN)、相邻正常R‐R间期差值>50ms的百分数(PNN50)、相邻窦性R‐R间期差值和均方根值(rMSSD)、高频(HF)水平均显著升高,低频(LF)水平显著下降(P均<0.05),血脂TC、TG、LDL‐C水平均显著降低, HDL‐C水平显著升高( P均<0.01),治疗后胸痛时间[(9.53±5.34) min比(6.32±2.13) min ]与频率[(3.87±1.13)次/d比(2.99±1.14)次/d]均显著降低(P均<0.01)。结论:常规治疗的同时联合非诺贝特治疗老年急性冠脉综合征能显著降低BNP水平、调节血脂并有助于自主神经功能的恢复。
目的:探討非諾貝特對老年急性冠脈綜閤徵(ACS)患者血漿腦鈉肽(BNP)及心率變異性(HRV)的影響。方法:選擇我院的ACS老年患者150例,隨機分成常規治療組和非諾貝特組(常規治療聯閤非諾貝特治療),各75例。對比治療前後患者血漿BNP水平、 HRV參數、血脂水平和胸痛的變化。結果:治療後,兩組 BNP , HRV和血脂水平均明顯改善(P均<0.01);與常規治療組比較,非諾貝特組血漿BNP水平[(132.5±22.1) pg/ml比(91.2±13.7) pg/ml]降低更顯著(P<0.01), HRV中正常竇性R‐R間期總體標準差(SDNN)、相鄰正常R‐R間期差值>50ms的百分數(PNN50)、相鄰竇性R‐R間期差值和均方根值(rMSSD)、高頻(HF)水平均顯著升高,低頻(LF)水平顯著下降(P均<0.05),血脂TC、TG、LDL‐C水平均顯著降低, HDL‐C水平顯著升高( P均<0.01),治療後胸痛時間[(9.53±5.34) min比(6.32±2.13) min ]與頻率[(3.87±1.13)次/d比(2.99±1.14)次/d]均顯著降低(P均<0.01)。結論:常規治療的同時聯閤非諾貝特治療老年急性冠脈綜閤徵能顯著降低BNP水平、調節血脂併有助于自主神經功能的恢複。
목적:탐토비낙패특대노년급성관맥종합정(ACS)환자혈장뇌납태(BNP)급심솔변이성(HRV)적영향。방법:선택아원적ACS노년환자150례,수궤분성상규치료조화비낙패특조(상규치료연합비낙패특치료),각75례。대비치료전후환자혈장BNP수평、 HRV삼수、혈지수평화흉통적변화。결과:치료후,량조 BNP , HRV화혈지수평균명현개선(P균<0.01);여상규치료조비교,비낙패특조혈장BNP수평[(132.5±22.1) pg/ml비(91.2±13.7) pg/ml]강저경현저(P<0.01), HRV중정상두성R‐R간기총체표준차(SDNN)、상린정상R‐R간기차치>50ms적백분수(PNN50)、상린두성R‐R간기차치화균방근치(rMSSD)、고빈(HF)수평균현저승고,저빈(LF)수평현저하강(P균<0.05),혈지TC、TG、LDL‐C수평균현저강저, HDL‐C수평현저승고( P균<0.01),치료후흉통시간[(9.53±5.34) min비(6.32±2.13) min ]여빈솔[(3.87±1.13)차/d비(2.99±1.14)차/d]균현저강저(P균<0.01)。결론:상규치료적동시연합비낙패특치료노년급성관맥종합정능현저강저BNP수평、조절혈지병유조우자주신경공능적회복。
Objective:To explore influence of fenofibrate on plasma level of brain natriuretic peptide (BNP) and heart rate variability (HRV) in aged patients with acute coronary syndrome (ACS) .Methods :A total of 150 aged ACS patients undergoing treatment in our hospital were selected ,randomly and equally divided into routine treat‐ment group and fenofibrate group .Changes of plasma BNP level ,HRV parameters , blood lipid levels ,and chest pain were compared between two groups before and after treatment .Results:After treatment ,BNP level signifi‐cantly reduced ,and HRV , blood lipid levels significantly improved in both groups , P<0.01 all .Compared with routine treatment group ,plasma BNP level significantly reduced [ (132.5 ± 22.1) pg/ml vs .(91.2 ± 13.7) pg/ml] ( P<0.01);there were significant rise in standard deviation of normal to normal RR intervals calculated over the 24 h period (SDNN) ,adjacent normal RR interval difference > 50ms stroke accounted for a percentage of 24h total RR interval (PNN50) ,root‐mean square of differences between successive normal to normal intervals (rMSSD) and high frequency (HF) ,and significant reduction in low frequency (LF) ,P<0.05 all;significant reductions in levels of TC ,TG and LDL‐C ,and significant rise in HDL‐C level ( P<0.01 all);there were significant reductions in on‐set duration [ (9.53 ± 5.34) min vs .(6.32 ± 2.13) min] and frequency [ (3.87 ± 1.13) times/d vs .(2.99 ± 1.14) times/d] of chest pain after treatment in fenofibrate group , P<0.01 both .Conclusion:Routine therapy combined fenofi‐brate can significantly reduce BNP level ,regulate blood lipid and autonomic nervous function in aged ACS patients .