CAJ | 학술논문

目的探讨幽门螺杆菌(HP)感染与不同性别人群血脂异常的关系.方法对2010年1月至2012年6月1 921例体检者进行包括人口学特征、人体测量学、生活方式等横断面分析,并检测血脂水平和HP感染情况,比较不同性别人群HP感染与血脂异常的关系.结果在女性人群中,HP感染阳性组总胆固醇/高密度脂蛋白胆固醇(TC/HDL)水平明显高于Hp感染阴性组(P＜0.05),低密度脂蛋白胆固醇(LDL-c)水平差异无统计学意义(P＞0.05).在男性人群中,HP感染阳性组LDL-c和TC/HDL-c水平均明显高于Hp感染阴性组(P＜0.05).相关分析显示,无论男女HP感染阳性组发生高TC/HDL-c血症的风险均增加,女性HP感染阳性组为Hp感染阴性组的1.90倍(95％ CI,1.06～3.38),男性HP感染阳性组为HP感染阴性组的1.56倍(95％ CI,1.21 ～2.00).而仅在男性人群中,HP感染阳性组发生高LDL-c血症的风险增加,HP感染阳性组是HP感染阴性组2.33倍(95％ CI,1.34 ～4.06).结论 HP感染可能引起机体血脂异常.
목적 탐토유문라간균(HP)감염여불동성별인군혈지이상적관계.방법 대2010년1월지2012년6월1 921례체검자진행포괄인구학특정、인체측량학、생활방식등횡단면분석,병검측혈지수평화HP감염정황,비교불동성별인군HP감염여혈지이상적관계.결과 재녀성인군중,HP감염양성조총담고순/고밀도지단백담고순(TC/HDL)수평명현고우Hp감염음성조(P＜0.05),저밀도지단백담고순(LDL-c)수평차이무통계학의의(P＞0.05).재남성인군중,HP감염양성조LDL-c화TC/HDL-c수평균명현고우Hp감염음성조(P＜0.05).상관분석현시,무론남녀HP감염양성조발생고TC/HDL-c혈증적풍험균증가,녀성HP감염양성조위Hp감염음성조적1.90배(95％ CI,1.06～3.38),남성HP감염양성조위HP감염음성조적1.56배(95％ CI,1.21 ～2.00).이부재남성인군중,HP감염양성조발생고LDL-c혈증적풍험증가,HP감염양성조시HP감염음성조2.33배(95％ CI,1.34 ～4.06).결론 HP감염가능인기궤체혈지이상.
Objective To assess the association between helicobacter pylori (HP) infection and dyslipidemia in different gender population.Methods We conducted cross-sectional analysis using data of 1921 cases of demographic characteristics,anthropometry,life style,lipid profile,etc.,from the subjects who received health examination from January 2010 to June 2012 in Department of Geriatrics,Tongji Hospital.Diagnosis of HP infection was achieved by using 14C-Urea Breath Test (14C-UBT).The participants were divided into HP infection positive group and HP infection negative group by 14C-UBT.Results In female subjects,the levels of total cholesterol/high-density lipoprotein cholesterol (TC/HDL-c) were higher in HP positive group than HP negative group (P ＜ 0.05),but there was no obvious difference between the levels of low density lipoprotein cholesterol (LDL-c) in HP positive group and HP negative group.However,in the male subjects,the levels of LDL-c and TC/HDL-c were significantly increased in HP positive group than HP negative group (P ＜ 0.05).HP positive group had a greater risk for high TC/HDL-c both in female and male subjects.In female subjects,the risk for high TC/HDL-c in HP positive group was 1.90 times of that in HP negative group (95％ CI,1.06 ～ 3.38).In male subjects,the risk for high TC/HDLc in HP positive group was 1.56 times of that in HP negative group (95％ CI,1.21 ～ 2.00).But only in male subjects,the risk for high LDL-c in HP positive group was 2.33 times of that in HP negative group (95 ％ CI,1.34 ～ 4.06).Conclusions We observed that HP infection was probability associated with dyslipidemia.