心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
Chinese Journal of Cardiovascular Rehabilitation Medicine
2015年
5期
557-561
,共5页
心肌梗死%支架%替罗非班
心肌梗死%支架%替囉非班
심기경사%지가%체라비반
Myocardial infarction%Stents%Tirofiban
目的：评价Firebird支架联合替罗非班用于急性心肌梗死（AMI）中的疗效及安全性。方法：选择2011年8月至2013年8月我院收治的86例AMI患者，依据随机数字表法患者被分为：联合治疗组（50例， Firebird支架联合替罗非班）和常规治疗组（36例，裸金属支架）。对患者进行12～18个月的随访，比较两组临床疗效、临床事件发生率。结果：PCI术后，与常规治疗组比较，联合治疗组患者TIMI分级1－2级比例（13.9％比4.0％）明显减少，3～4级比例（86.1％比96.0％）明显增加，校正TIMI计帧数[（29.2±4.4）比（21.4±5.1）]明显减少， P均＜0.05；术后6个月，与常规治疗组比较，联合治疗组的亚急性血栓（2.8％比0％）、心肌梗死（2.8％比0％）发生率均明显降低（ P均＜0.05），术后12个月，与常规治疗组比较，联合治疗组的心绞痛（16.7％比6.0％）、亚急性血栓（11.1％比0％）、心肌梗死（8.3％比0％）、心力衰竭（2.8％比0％）、再入院（11.1％比0％）发生率均明显降低（P＜0.05或＜0.01）。结论：Firebird支架联合替罗非班用于急性心肌梗死中的疗效显著，且安全可靠，值得推广。
目的：評價Firebird支架聯閤替囉非班用于急性心肌梗死（AMI）中的療效及安全性。方法：選擇2011年8月至2013年8月我院收治的86例AMI患者，依據隨機數字錶法患者被分為：聯閤治療組（50例， Firebird支架聯閤替囉非班）和常規治療組（36例，裸金屬支架）。對患者進行12～18箇月的隨訪，比較兩組臨床療效、臨床事件髮生率。結果：PCI術後，與常規治療組比較，聯閤治療組患者TIMI分級1－2級比例（13.9％比4.0％）明顯減少，3～4級比例（86.1％比96.0％）明顯增加，校正TIMI計幀數[（29.2±4.4）比（21.4±5.1）]明顯減少， P均＜0.05；術後6箇月，與常規治療組比較，聯閤治療組的亞急性血栓（2.8％比0％）、心肌梗死（2.8％比0％）髮生率均明顯降低（ P均＜0.05），術後12箇月，與常規治療組比較，聯閤治療組的心絞痛（16.7％比6.0％）、亞急性血栓（11.1％比0％）、心肌梗死（8.3％比0％）、心力衰竭（2.8％比0％）、再入院（11.1％比0％）髮生率均明顯降低（P＜0.05或＜0.01）。結論：Firebird支架聯閤替囉非班用于急性心肌梗死中的療效顯著，且安全可靠，值得推廣。
목적：평개Firebird지가연합체라비반용우급성심기경사（AMI）중적료효급안전성。방법：선택2011년8월지2013년8월아원수치적86례AMI환자，의거수궤수자표법환자피분위：연합치료조（50례， Firebird지가연합체라비반）화상규치료조（36례，라금속지가）。대환자진행12～18개월적수방，비교량조림상료효、림상사건발생솔。결과：PCI술후，여상규치료조비교，연합치료조환자TIMI분급1－2급비례（13.9％비4.0％）명현감소，3～4급비례（86.1％비96.0％）명현증가，교정TIMI계정수[（29.2±4.4）비（21.4±5.1）]명현감소， P균＜0.05；술후6개월，여상규치료조비교，연합치료조적아급성혈전（2.8％비0％）、심기경사（2.8％비0％）발생솔균명현강저（ P균＜0.05），술후12개월，여상규치료조비교，연합치료조적심교통（16.7％비6.0％）、아급성혈전（11.1％비0％）、심기경사（8.3％비0％）、심력쇠갈（2.8％비0％）、재입원（11.1％비0％）발생솔균명현강저（P＜0.05혹＜0.01）。결론：Firebird지가연합체라비반용우급성심기경사중적료효현저，차안전가고，치득추엄。
Objective:To evaluate therapeutic effect and safety of Firebird stent combined tirofiban on acute myocar‐dial infarction (AMI) .Methods :A total of 86 AMI patients treated in our hospital from Aug 2011 to Aug 2013 were selected .According to random number table method ,patients were divided into combined treatment group (n=50 , received Firebird stenting combined tirofiban treatment ) and routine treatment group (n=36 ,received bare metal stenting) .Patients were followed up for 12~18 months ,therapeutic effects ,incidence rates of clinical events were compared between two groups .Results:After PCI ,compared with routine treatment group ,there were significant reductions in percentage of TIMI class 1~2 (13.9% vs .4.0% ) and corrected TIMI frame [ (29.2 ± 4.4) vs .(21.4 ± 5.1)] ,significant rise in percentage of TIMI class 3~4 (86.1% vs .96.0% ) in combined treatment group , P<0.05 all;on six months after PCI ,compared with routine treatment group ,there were significant reductions in inci‐dence rates of subacute thrombosis (2.8% vs .0% ) and myocardial infarction (2.8% vs . 0% ) in combined treat‐ment group (P<0.05 both);on 12 months after operation ,compared with routine treatment group ,there were sig‐nificant reductions in incidence rates of angina pectoris (16.7% vs .6.0% ) ,subacute thrombosis rate (11.1% vs . 0% ) ,myocardial infarction (8.3% vs .0% ) ,heart failure (2.8% vs .0% ) and rehospitalization rate (11.1% vs . 0% ) in combined treatment group , P<0.05 or <0.01 .Conclusion:Firebird stent combined tirofiban possesses sig‐nificant therapeutic effect on acute myocardial infarction ,and it's safe and reliable ,which is worth extending .
