CAJ | 학술논문

目的探讨中枢神经细胞瘤的诊断及治疗体会.方法安徽医科大学第一附属医院神经外科自2004年1月至2014年6月共收治中枢神经细胞瘤患者9例,其中脑室内中枢神经细胞瘤(CNC)6例,脑室外神经细胞瘤(EVN)3例.回顾性分析患者的临床资料、诊断治疗及预后.结果 6例CNC患者中肿瘤全切3例,次全切除2例,大部分切除1例;3例EVN患者中肿瘤全切2例,次全切除1例;CNC和EVN病理学特征相似,均可见类似神经毡样的神经纤维无核区;次全切除和大部分切除患者术后行放射治疗.随访24～72个月,无复发病例;1例患者术后出现面瘫,半年随访时好转.结论脑室内、外中枢神经细胞瘤病理学特征相似,但临床、影像学表现、预后不同.显微手术全切除肿瘤是提高患者预后的关键,术后辅以放、化疗可控制残留肿瘤的生长,延缓复发.
목적 탐토중추신경세포류적진단급치료체회.방법 안휘의과대학제일부속의원신경외과자2004년1월지2014년6월공수치중추신경세포류환자9례,기중뇌실내중추신경세포류(CNC)6례,뇌실외신경세포류(EVN)3례.회고성분석환자적림상자료、진단치료급예후.결과 6례CNC환자중종류전절3례,차전절제2례,대부분절제1례;3례EVN환자중종류전절2례,차전절제1례;CNC화EVN병이학특정상사,균가견유사신경전양적신경섬유무핵구;차전절제화대부분절제환자술후행방사치료.수방24～72개월,무복발병례;1례환자술후출현면탄,반년수방시호전.결론 뇌실내、외중추신경세포류병이학특정상사,단림상、영상학표현、예후불동.현미수술전절제종류시제고환자예후적관건,술후보이방、화료가공제잔류종류적생장,연완복발.
Objective To explore the clinical manifestations,pathological features,imaging findings,microsurgical treatment effectiveness and prognosis of intraventricular central neurocytoma (CNC) and extraventricular neurocytoma (EVN).Methods The clinical data of nine patients with intracranial neurocytomas,admitted to our hospital from January 2004 to June 2014,were retrospectively analyzed.A comparative study of clinical manifestations,pathological features,imaging findings,microsurgical treatment effectiveness and prognosis of CNC (n=6) and EVN (n=3) was performed.Results In the six patients with CNC,total removal of the lesions was achieved in 3,subtotal removal in 2 and partial removal in 1.In the three patients with EVN,total removal of the lesions was achieved in 2 and subtotal removal in 1.The pathological features of CNC and EVN were similar,showing nerve fibers without nuclear.No recurrence was noted in 24-72 months of follow-up.Facial paralysis occurred in a young male patient and recovered after 6 months.Conclusions CNC and EVN share the same pathological characters,but have different clinical presentations,image findings and prognoses.Total removal of the tumor plays a key role in improving the prognosis of the patients.Adjuvant radiotherapy and chemical therapy can control the progress of residual tumor and delay the recurrence of it.