CAJ | 학술논문

目的分析血管中心性胶质瘤患者的临床、影像、病理学特点和疗效.方法首都医科大学三博脑科医院神经外科自2011年1月1日至2015年3月31日收治、经病理确诊的血管中心性胶质瘤患者8例,回顾性分析患者的临床、影像、病理学资料和疗效.结果 8例患者中1例以间断头晕起病,7例以癫痫起病;肿瘤MRI表现为T1WI低信号,T2WI等、高信号.部分患者的CT显示有钙化;肿瘤WHO分级Ⅰ～Ⅱ级,镜下肿瘤细胞呈双极、圆形、卵圆形或梭形,围绕毛细血管生长,瘤细胞表达神经胶质纤维酸性蛋白(GFAP)等神经胶质细胞标记物,同时部分表达神经元核抗原(NeuN)、突触素(Syn)等神经元的标记物;手术治疗后MRI显示8例患者瘤体均全切除,随访6～47个月患者无癫痫发作、无肿瘤复发及死亡;结论血管中心性胶质瘤是一种青少年起病的低度恶性肿瘤,可能是起源于放射状胶质细胞的一种神经-胶质细胞肿瘤.手术治疗效果较好.
목적 분석혈관중심성효질류환자적림상、영상、병이학특점화료효.방법 수도의과대학삼박뇌과의원신경외과자2011년1월1일지2015년3월31일수치、경병리학진적혈관중심성효질류환자8례,회고성분석환자적림상、영상、병이학자료화료효.결과 8례환자중1례이간단두훈기병,7례이전간기병;종류MRI표현위T1WI저신호,T2WI등、고신호.부분환자적CT현시유개화;종류WHO분급Ⅰ～Ⅱ급,경하종류세포정쌍겁、원형、란원형혹사형,위요모세혈관생장,류세포표체신경효질섬유산성단백(GFAP)등신경효질세포표기물,동시부분표체신경원핵항원(NeuN)、돌촉소(Syn)등신경원적표기물;수술치료후MRI현시8례환자류체균전절제,수방6～47개월환자무전간발작、무종류복발급사망;결론 혈관중심성효질류시일충청소년기병적저도악성종류,가능시기원우방사상효질세포적일충신경-효질세포종류.수술치료효과교호.
Objective To investigate the clinical,imaging and pathological characteristics of angiocentric gliomas (AG) in Chinese patients,and provide opinions for diagnosis and treatment of the disease.Methods Eight patients with AG confirmed by histology in our hospital from January 1,2011 to March 31,2015,were chosen in our study;the clinical,imaging,and pathological data were retrospectively analyzed.Results In these 8 patients,one had onset of dizzy giddy and the other 7 had onset of epilepsy.T1-weighted imaging hypointense signal and T2-weighted imaging isointense or hyperintense signals were noted.CT scan showed calcification in 3 patients.Pathology indicated WHO grade Ⅰ-Ⅱ gliomas.Neoplastic cells were bipolar,round,oval or spindle shaped around capillary,and they expressed both glial markers (glial fibrillary acidic protein) and neuronal markers (neuronal nuclei antigen and synaptophysin).MR imaging showed that all the 8 patients got total resection,and follow up of 6-47 months recorded no epileptic seizure,neoplasm recurrence or death.Conclusions AG is a kind of low-grade glioma in children or young adults.And it may be a mixed neuronal-glial neoplasm originating from radial glia,enjoying good surgical effects.