中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
Chinese Journal of Medical Genetics
2015年
5期
711-714
,共4页
韩琳%辛若赛%孙健%侯峰%李长贵%胡新林%刘振%王瑶%李鑫德
韓琳%辛若賽%孫健%侯峰%李長貴%鬍新林%劉振%王瑤%李鑫德
한림%신약새%손건%후봉%리장귀%호신림%류진%왕요%리흠덕
2型糖尿病%痛风%单核苷酸多态性
2型糖尿病%痛風%單覈苷痠多態性
2형당뇨병%통풍%단핵감산다태성
Type 2 diabetes mellitus%Gout%Single nucleotide polymorphism
目的 探讨2型糖尿病(type 2 diabetes mellitus,T2DM)易感基因多态性位点(single nucleotide polymorphism,SNP)与山东沿海地区汉族男性痛风的相关性.方法 选取山东沿海地区480例汉族男性痛风患者和480名汉族男性健康体检者为对照组,应用Illumina GoldenGate基因芯片对研究人群的DNA进行分型,应用x2检验进行关联性分析.结果 7个SNPs位点基因型频率及等位基因频率与对照组比较差异均无统计学意义(均P＞0.05).结论 T2DM易感基因WNT5B (rs10773971、rs4766398)、JAZF1(rs10225163)、BDKRB2 (rs2069590)、HGF (rs5745709)、OTOP1 (rs1991914)、COL18A1(rs2236479)位点多态性与山东沿海地区汉族男性痛风患者易感性无关联性,但仍需进一步扩大样本量,并选择不同地区、种族和更多的位点进一步验证.
目的 探討2型糖尿病(type 2 diabetes mellitus,T2DM)易感基因多態性位點(single nucleotide polymorphism,SNP)與山東沿海地區漢族男性痛風的相關性.方法 選取山東沿海地區480例漢族男性痛風患者和480名漢族男性健康體檢者為對照組,應用Illumina GoldenGate基因芯片對研究人群的DNA進行分型,應用x2檢驗進行關聯性分析.結果 7箇SNPs位點基因型頻率及等位基因頻率與對照組比較差異均無統計學意義(均P＞0.05).結論 T2DM易感基因WNT5B (rs10773971、rs4766398)、JAZF1(rs10225163)、BDKRB2 (rs2069590)、HGF (rs5745709)、OTOP1 (rs1991914)、COL18A1(rs2236479)位點多態性與山東沿海地區漢族男性痛風患者易感性無關聯性,但仍需進一步擴大樣本量,併選擇不同地區、種族和更多的位點進一步驗證.
목적 탐토2형당뇨병(type 2 diabetes mellitus,T2DM)역감기인다태성위점(single nucleotide polymorphism,SNP)여산동연해지구한족남성통풍적상관성.방법 선취산동연해지구480례한족남성통풍환자화480명한족남성건강체검자위대조조,응용Illumina GoldenGate기인심편대연구인군적DNA진행분형,응용x2검험진행관련성분석.결과 7개SNPs위점기인형빈솔급등위기인빈솔여대조조비교차이균무통계학의의(균P＞0.05).결론 T2DM역감기인WNT5B (rs10773971、rs4766398)、JAZF1(rs10225163)、BDKRB2 (rs2069590)、HGF (rs5745709)、OTOP1 (rs1991914)、COL18A1(rs2236479)위점다태성여산동연해지구한족남성통풍환자역감성무관련성,단잉수진일보확대양본량,병선택불동지구、충족화경다적위점진일보험증.
Objective To assess the association of single nucleotide polymorphisms (SNPs) of susceptibility genes of type 2 diabetes mellitus (T2DM) with liability to gout among ethnic Han Chinese males from coastal region of Shandong province.Methods Seven SNPs within the susceptibility genes of T2DM, including rs10773971 (G/C) and rs4766398 (G/C) of WNT5B gene, rs10225163 (G/C) of JAZF1 gene, rs2069590(T/A) of BDKRB2 gene, rs5745709 (G/A) of HGF gene, rs1991914 (C/A) of OTOP1 gene and rs2236479 (G/A) of COL18A1 gene, were typed with a custom-made Illumina GoldenGate Genotyping assay in 480 male patients with gout and 480 male controls.Potential association was assessed with the x2 test.Results No significant difference was detected for the 7 selected SNPs in terms of genotypic and allelic frequencies (P＞0.05).When age and body mass index (BMI) were adjusted, the 7 genetic variants still showed no significant association with gout.Conclusion The genotypes of the 7 selected SNPs are not associated with gout in ethnic Han Chinese male patients from the coastal region of Shandong province.However, the results need to be replicated in larger sets of patients collected from other regions and populations.
