中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
Chinese Journal of Medical Genetics
2015年
5期
723-727
,共5页
何苗%刘振%唐北沙%王俊岭
何苗%劉振%唐北沙%王俊嶺
하묘%류진%당북사%왕준령
清道夫受体B2%β-葡萄糖脑苷脂酶%进行性肌阵挛癫痫%戈谢病%手足口病
清道伕受體B2%β-葡萄糖腦苷脂酶%進行性肌陣攣癲癇%戈謝病%手足口病
청도부수체B2%β-포도당뇌감지매%진행성기진련전간%과사병%수족구병
SCARB2 gene%β-glucocerebrosidase%Progressive myoclonus epilepsy%Gaucher disease%Hand-foot-and-mouth disease
清道夫受体B2蛋白(scavenger receptor class B,member 2,SCARB2)由SCARB2基因编码,是一种溶酶体膜糖蛋白,在介导溶酶体蛋白β-葡萄糖脑苷脂酶的转运,EV71病毒的感染与心肌的代偿性肥厚等生理病理过程中发挥重要作用.与进行性肌阵挛癫痫、戈谢病、心肌炎、手足口病等疾病有不同程度的关联.对SCARB2基因、蛋白的结构、功能及与疾病的关系等方面进行综述.
清道伕受體B2蛋白(scavenger receptor class B,member 2,SCARB2)由SCARB2基因編碼,是一種溶酶體膜糖蛋白,在介導溶酶體蛋白β-葡萄糖腦苷脂酶的轉運,EV71病毒的感染與心肌的代償性肥厚等生理病理過程中髮揮重要作用.與進行性肌陣攣癲癇、戈謝病、心肌炎、手足口病等疾病有不同程度的關聯.對SCARB2基因、蛋白的結構、功能及與疾病的關繫等方麵進行綜述.
청도부수체B2단백(scavenger receptor class B,member 2,SCARB2)유SCARB2기인편마,시일충용매체막당단백,재개도용매체단백β-포도당뇌감지매적전운,EV71병독적감염여심기적대상성비후등생리병리과정중발휘중요작용.여진행성기진련전간、과사병、심기염、수족구병등질병유불동정도적관련.대SCARB2기인、단백적결구、공능급여질병적관계등방면진행종술.
SCARB2 (scavenger receptor class B, member 2) is a lysosomal membrane glucoprotein, which is encoded by SCARB2 gene.It takes vital parts in the physiological and pathological processes including the transportation of β-glucocerebrosidase to the lysosome, infection of EV71 and load-induced cardiac myocyte hypertrophy.This article has reviewed the molecular structure and functions of SCARB2 gene and its protein, as well as their relationship with diseases.