CAJ | 학술논문

类风湿关节炎(rheumatoid arthritis,RA)是一种慢性、炎性、自身免疫性疾病,主要累及关节和滑膜,其发病机制尚待探明,遗传因素在RA的发病中起着重要作用.RA的易感基因除人类白细胞抗原(humanleukocyte antigen,HLA)区域的HLA-DRB等基因外,还有非HLA区域的TIM-3、PTPN22、TRAF1/C5、STAT4、CCR5、PADI4、FCGR2A等基因.
류풍습관절염(rheumatoid arthritis,RA)시일충만성、염성、자신면역성질병,주요루급관절화활막,기발병궤제상대탐명,유전인소재RA적발병중기착중요작용.RA적역감기인제인류백세포항원(humanleukocyte antigen,HLA)구역적HLA-DRB등기인외,환유비HLA구역적TIM-3、PTPN22、TRAF1/C5、STAT4、CCR5、PADI4、FCGR2A등기인.
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disorder that principally attacks flexible joints and synovia.The precise pathogenesis of RA remains unclear, and genetic factors probably play an important role in its etiology.In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM 3、PTPN22, TRAF1/C5,STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility.The advance in molecular genetics research on RA is reviewed here.