实用医学杂志
實用醫學雜誌
실용의학잡지
The Journal of Practical Medicine
2015年
20期
3347-3350
,共4页
王林娜%侯素平%刘洪博%孙晓玲%张晓娟%张清泉
王林娜%侯素平%劉洪博%孫曉玲%張曉娟%張清泉
왕림나%후소평%류홍박%손효령%장효연%장청천
结直肠肿瘤%REG4%Survivin%组织芯片%免疫组化
結直腸腫瘤%REG4%Survivin%組織芯片%免疫組化
결직장종류%REG4%Survivin%조직심편%면역조화
Colorectal neoplasms%REG4%Survivin%Tissue microarray%Immunohistochemistry
目的：检测REG4与survivin在结直肠癌组织内的表达，并分析二者与临床病理特征的关系。方法：应用免疫组化结合组织芯片的方法，检测92例结直肠癌患者癌组织及相应正常黏膜组织内REG4与survivin的表达情况。结果：结直肠癌患者组织中REG4与survivin表达阳性率为53．3％（49／92）与64．1％（59／92），正常黏膜组织内REG4与survivin的阳性率为8．7％（8／92）与3．3％（3／92），差异有统计学意义（P ＜0．05）；REG4与结直肠癌的分化程度、淋巴结转移及TNM分期密切相关，survivin与淋巴结转移及TNM分期相关（P ＜0．05）；结直肠癌患者组织内REG4与survivin的表达呈正相关（r ＝0．208，P ＜0．05）。结论：REG4与survivin在结直肠癌组织内过表达，提示两者共同参与了结直肠癌的发生与发展，检测REG4和survivin可为结直肠癌的治疗及预后提供理论支持。
目的：檢測REG4與survivin在結直腸癌組織內的錶達，併分析二者與臨床病理特徵的關繫。方法：應用免疫組化結閤組織芯片的方法，檢測92例結直腸癌患者癌組織及相應正常黏膜組織內REG4與survivin的錶達情況。結果：結直腸癌患者組織中REG4與survivin錶達暘性率為53．3％（49／92）與64．1％（59／92），正常黏膜組織內REG4與survivin的暘性率為8．7％（8／92）與3．3％（3／92），差異有統計學意義（P ＜0．05）；REG4與結直腸癌的分化程度、淋巴結轉移及TNM分期密切相關，survivin與淋巴結轉移及TNM分期相關（P ＜0．05）；結直腸癌患者組織內REG4與survivin的錶達呈正相關（r ＝0．208，P ＜0．05）。結論：REG4與survivin在結直腸癌組織內過錶達，提示兩者共同參與瞭結直腸癌的髮生與髮展，檢測REG4和survivin可為結直腸癌的治療及預後提供理論支持。
목적：검측REG4여survivin재결직장암조직내적표체，병분석이자여림상병리특정적관계。방법：응용면역조화결합조직심편적방법，검측92례결직장암환자암조직급상응정상점막조직내REG4여survivin적표체정황。결과：결직장암환자조직중REG4여survivin표체양성솔위53．3％（49／92）여64．1％（59／92），정상점막조직내REG4여survivin적양성솔위8．7％（8／92）여3．3％（3／92），차이유통계학의의（P ＜0．05）；REG4여결직장암적분화정도、림파결전이급TNM분기밀절상관，survivin여림파결전이급TNM분기상관（P ＜0．05）；결직장암환자조직내REG4여survivin적표체정정상관（r ＝0．208，P ＜0．05）。결론：REG4여survivin재결직장암조직내과표체，제시량자공동삼여료결직장암적발생여발전，검측REG4화survivin가위결직장암적치료급예후제공이론지지。
Objective To explore the expression of REG4 and survivin in colorectal cancer, and to analyze the relationship with clinicopathologic features. Methods The expression of REG4 and survivin in 92 colorectal cancer and corresponding normal mucosa was evaluated by immunohistochemistry combining tissue microarray. The relationship between REG4 and survivin and clinicopathologic parameters were statistically assessed. Results The positive expression of REG4 and survivin in colorectal cancer were 53.3% (49/92) and 64.1% (59/92). The positive rates were 8.6% (8/92) and 3.3% (3/92) in the normal mucosa. The level of both REG4 and survivin in colorectal cancer was significantly higher than that in normal mucosa (P < 0.05). REG4 expression was related to differentiation, lymph node metastasis and TNM stage, while survivin was significantly correlated with the lymph node metastasis and TNM stage (P < 0.05). Both were not correlated with the patient′s gender, age, tumor size (P > 0.05). REG4 expression was positively associated with survivin (r =0.208, P<0.05). Conclusion REG4 and survivin were upregulated in colorectal carcinoma, and may be involved in the occurrence of colorectal cancer.
