CAJ | 학술논문

目的：探讨胸水和血清中肿瘤标志物癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）、神经元特异性烯醇化酶（NSE）、鳞状细胞癌抗原（SCC-Ag）联合检测在肺癌中的诊断价值。方法：回顾性分析临床已确诊的101例患者胸水及血清中四项肿瘤标志物水平，应用ROC曲线建立合理的临床诊断临界值，比较各肿瘤标志物在不同病理类型肺癌表达情况。结果：肺癌组胸水和血清中四项肿瘤标志物水平均高于良性组（P ＜0．05），CEA对肺腺癌、NSE对小细胞肺癌、CYFRA21-1和SCC-Ag对肺鳞癌在胸水和血清中表达水平和阳性率高于其他单项检测（P ＜0．05）；胸水和血清联合检测可提高肺癌检出率。结论：胸水和血清肿瘤标志物联合检测对肺癌检出及病理分型具有重要的参考价值。
목적：탐토흉수화혈청중종류표지물암배항원（CEA）、세포각단백19편단（CYFRA21-1）、신경원특이성희순화매（NSE）、린상세포암항원（SCC-Ag）연합검측재폐암중적진단개치。방법：회고성분석림상이학진적101례환자흉수급혈청중사항종류표지물수평，응용ROC곡선건립합리적림상진단림계치，비교각종류표지물재불동병리류형폐암표체정황。결과：폐암조흉수화혈청중사항종류표지물수평균고우량성조（P ＜0．05），CEA대폐선암、NSE대소세포폐암、CYFRA21-1화SCC-Ag대폐린암재흉수화혈청중표체수평화양성솔고우기타단항검측（P ＜0．05）；흉수화혈청연합검측가제고폐암검출솔。결론：흉수화혈청종류표지물연합검측대폐암검출급병리분형구유중요적삼고개치。
Objective To investigate the values of combined determination of pleural effusion and serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific enolase (NSE), and squamous cell carcinoma antigen (SCC-Ag) in diagnosis of lung cancer. Methods 101 patients with pleural effusion were reviewed retrospectively. Expressions of CEA, CYFRA21-1, NSE and SCC-Ag in pleural fluid and serum were detected; the optimum cut-off points resulting from the best sensitivity-specificity balance in the receiver operator characteristic (ROC) curves were constructed. The expressions of the tumor markers were compared among different pathological types of lung cancer. Results The levels of tumor markers in both pleural effusion and serum were significantly higher in patients with lung cancer than the benign group (P < 0.05). The expression levels and positive rate of CEA for lung adenocarcinoma, NSE for small cell lung cancer, and CYFRA21-1and SCC-Ag for pulmonary squamous cell carcinoma were higher than any other single detection (P < 0.05). Combined detection of the tumor markers in pleural fluid and serum improved the detection rate of lung cancer. Conclusions Combined detection of pleural effusion and serum tumor markers has important reference value in the detection of lung cancer and in pathological typing.