中国老年学杂志
中國老年學雜誌
중국노년학잡지
Chinese Journal of Gerontology
2015年
21期
6008-6011
,共4页
郎艳松%秘红英%刘美之%袁国强
郎豔鬆%祕紅英%劉美之%袁國彊
랑염송%비홍영%류미지%원국강
外膜%炎症%动脉粥样硬化%MCP-1%IL-8%IL-10
外膜%炎癥%動脈粥樣硬化%MCP-1%IL-8%IL-10
외막%염증%동맥죽양경화%MCP-1%IL-8%IL-10
Adventitia%Inflammation%Atherosclerosis%MCP-1%IL-8%IL-10
目的:探讨“金三角”( ATS)方案即通心络联合阿托伐他汀、阿司匹林对家兔动脉粥样硬化早期颈动脉外膜炎症因子表达的影响。方法高脂饮食复合单侧颈总动脉硅胶管包裹制备兔动脉粥样硬化早期模型。72只新西兰兔随机分为对照组、模型组、通心络( TXL)组、阿托伐他汀( ATO)组、阿司匹林( ASP)组和ATS组,每组12只。对照组给予普通饲料、模型组及各用药组家兔均实施单侧颈动脉硅胶管包裹术复合高脂饲料喂养,TXL组给予通心络超微粉混悬液0.3 g? kg-1? d-1灌胃,ATO组给予阿托伐他汀2.5 mg? kg-1? d-1灌胃,ASP组给予阿司匹林12 mg? kg-1? d-1灌胃,ATS组给予TxL、ATO、ASP三者联合,剂量上,灌胃,连续给药,4 w 后取材,HE 染色判定颈动脉内中膜病理形态变化,生化法检测血脂变化, ELISA法测定各组家兔颈动脉包裹段外膜单核细胞趋化蛋白( MCP)-1、白介素( IL)-1β、IL-10表达水平,免疫组化法检测血管外膜 IL-8表达水平。结果与对照组比较,模型组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)表达明显增强(P<0.01)。与模型组比较,除 ASP组外,各用药组TC、TG、LDL-C表达明显减弱(P<0.01)。与其他用药组比较,ATS组TC、TG、LDL-C表达明显减弱(P<0.01)。与对照组比较,模型组颈动脉外膜中MCP-1、IL-1β表达明显增强,IL-10表达减弱(均P<0.01)。与模型组比较,各用药组颈动脉外膜中 MCP-1、IL-1β表达减弱(P<0.01),IL-10表达增强(P<0.05)。与其他用药组比较,ATS组MCP-1、IL-1β表达明显减弱,IL-10表达明显增强(均 P<0.01)。各用药组颈动脉外膜 IL-8表达减少。结论 TXL、ATO、ASP三药联用可通过降脂、调节血管外膜炎症反应从而有效延缓动脉粥样硬化进程,且较单药应用作用更佳。
目的:探討“金三角”( ATS)方案即通心絡聯閤阿託伐他汀、阿司匹林對傢兔動脈粥樣硬化早期頸動脈外膜炎癥因子錶達的影響。方法高脂飲食複閤單側頸總動脈硅膠管包裹製備兔動脈粥樣硬化早期模型。72隻新西蘭兔隨機分為對照組、模型組、通心絡( TXL)組、阿託伐他汀( ATO)組、阿司匹林( ASP)組和ATS組,每組12隻。對照組給予普通飼料、模型組及各用藥組傢兔均實施單側頸動脈硅膠管包裹術複閤高脂飼料餵養,TXL組給予通心絡超微粉混懸液0.3 g? kg-1? d-1灌胃,ATO組給予阿託伐他汀2.5 mg? kg-1? d-1灌胃,ASP組給予阿司匹林12 mg? kg-1? d-1灌胃,ATS組給予TxL、ATO、ASP三者聯閤,劑量上,灌胃,連續給藥,4 w 後取材,HE 染色判定頸動脈內中膜病理形態變化,生化法檢測血脂變化, ELISA法測定各組傢兔頸動脈包裹段外膜單覈細胞趨化蛋白( MCP)-1、白介素( IL)-1β、IL-10錶達水平,免疫組化法檢測血管外膜 IL-8錶達水平。結果與對照組比較,模型組總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)錶達明顯增彊(P<0.01)。與模型組比較,除 ASP組外,各用藥組TC、TG、LDL-C錶達明顯減弱(P<0.01)。與其他用藥組比較,ATS組TC、TG、LDL-C錶達明顯減弱(P<0.01)。與對照組比較,模型組頸動脈外膜中MCP-1、IL-1β錶達明顯增彊,IL-10錶達減弱(均P<0.01)。與模型組比較,各用藥組頸動脈外膜中 MCP-1、IL-1β錶達減弱(P<0.01),IL-10錶達增彊(P<0.05)。與其他用藥組比較,ATS組MCP-1、IL-1β錶達明顯減弱,IL-10錶達明顯增彊(均 P<0.01)。各用藥組頸動脈外膜 IL-8錶達減少。結論 TXL、ATO、ASP三藥聯用可通過降脂、調節血管外膜炎癥反應從而有效延緩動脈粥樣硬化進程,且較單藥應用作用更佳。
목적:탐토“금삼각”( ATS)방안즉통심락연합아탁벌타정、아사필림대가토동맥죽양경화조기경동맥외막염증인자표체적영향。방법고지음식복합단측경총동맥규효관포과제비토동맥죽양경화조기모형。72지신서란토수궤분위대조조、모형조、통심락( TXL)조、아탁벌타정( ATO)조、아사필림( ASP)조화ATS조,매조12지。대조조급여보통사료、모형조급각용약조가토균실시단측경동맥규효관포과술복합고지사료위양,TXL조급여통심락초미분혼현액0.3 g? kg-1? d-1관위,ATO조급여아탁벌타정2.5 mg? kg-1? d-1관위,ASP조급여아사필림12 mg? kg-1? d-1관위,ATS조급여TxL、ATO、ASP삼자연합,제량상,관위,련속급약,4 w 후취재,HE 염색판정경동맥내중막병리형태변화,생화법검측혈지변화, ELISA법측정각조가토경동맥포과단외막단핵세포추화단백( MCP)-1、백개소( IL)-1β、IL-10표체수평,면역조화법검측혈관외막 IL-8표체수평。결과여대조조비교,모형조총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)표체명현증강(P<0.01)。여모형조비교,제 ASP조외,각용약조TC、TG、LDL-C표체명현감약(P<0.01)。여기타용약조비교,ATS조TC、TG、LDL-C표체명현감약(P<0.01)。여대조조비교,모형조경동맥외막중MCP-1、IL-1β표체명현증강,IL-10표체감약(균P<0.01)。여모형조비교,각용약조경동맥외막중 MCP-1、IL-1β표체감약(P<0.01),IL-10표체증강(P<0.05)。여기타용약조비교,ATS조MCP-1、IL-1β표체명현감약,IL-10표체명현증강(균 P<0.01)。각용약조경동맥외막 IL-8표체감소。결론 TXL、ATO、ASP삼약련용가통과강지、조절혈관외막염증반응종이유효연완동맥죽양경화진정,차교단약응용작용경가。
Objective To discuss the effect of Tongxinluo combined with atorvastatin ( ATO)and aspirin( ASP) on the adventitia in-flammation of early atherosclerosis lesions in rabbits .Mtehod s Seventy-two New Zealand rabbits were randomly divided into control,model, tongxinluo(TXL),ATO,ASP,golden triangle(Tongxinluo combined with ATO and ASP,ATS) groups(n=12).All the groups were fed with medicine for 4 weeks.The tissue slice of carotid artery was stained by HE and observed under light microscope.The changes of blood liquid were detected by biochemical assay.ELISA was used to measure the carotid artery adventitia of MCP-1,IL-1β,IL-10.The immunohistochemi-cal staining was used to detect the protein expression of IL -8 around the carotid artery adventitia.Results Compared with those of normal group,the contents of TC,TG,LDL-C were significantly increased(P<0.01),the content of IL-10 was significantly decreased(P<O.01)in model group.Compared with those of model group,the contents of TC,TG,LDL -C were significantly decreased(P<0.01,P<0.05)in TXL and ATO groups,but no significant difference between TXL and ATO groups(P>0.05).In ATS group,the contents of TC,TG,LDL-C were lower than those in ATO and TXL groups(P<0.01).Compared with those of normal group,the contents of MCP-1,IL-1βwere significantly in-creased(P<0.01),the content of IL-10 was significantly decreased(P<0.01)in model group.Compared with those of model group,the con-tents of MCP-1,IL-1βwere decreased(P<0.01)in TXL,ATO and ASP groups,but no significant differences between the three groups( P>0.05).The content of IL-10 was decreased(P<0.01,P<0.05)in ATS group,the contents of TC,TG,LDL-C were lower than those in TXL, ATO and ASP groups(P<0.01).The content of IL-8 was decreased in TXL,ATO,ASP and ATS groups.Conclusions The ATS project could enhance the effect of regulating lipid metabolism and inhibiting the adventitia inflammation .It played an important role to intervene in the process of atherosclerosis.