CAJ | 학술논문

目的：探讨妊娠期糖尿病（ gestational diabetes mellitus ，GDM）高危孕妇甲状腺功能的变化。方法选取浙江苍南县人民医院产科2013年2月至2014年6月GDM高危孕妇80例，将其设为A1组（高危组）；选择GDM孕妇80例，设为A2组（糖尿病组）；选择正常健康孕妇80例，设为A3组（对照组）；对3组孕妇甲状腺功能指标进行检测，并进行比较分析。结果 A1与A2组的TPOAb阳性率水平显著高于A3组，差异有统计学意义（P＜0.05）；3组孕妇的TSH、FT3指标比较差异无统计学意义（P＞0.05），但A1与A2组的FT4水平显著低于A3组，差异有统计学意义（ P＜0.05）。结论 GDM孕妇及高危孕妇出现甲状腺功能异常的概率较正常健康孕妇更高，特别是有糖尿病家族史的孕妇，临床上应全面检查其甲状腺功能，防止因甲状腺功能紊乱对患者妊娠造成严重的影响，有效保证患者临床安全性。
목적：탐토임신기당뇨병（ gestational diabetes mellitus ，GDM）고위잉부갑상선공능적변화。방법선취절강창남현인민의원산과2013년2월지2014년6월GDM고위잉부80례，장기설위A1조（고위조）；선택GDM잉부80례，설위A2조（당뇨병조）；선택정상건강잉부80례，설위A3조（대조조）；대3조잉부갑상선공능지표진행검측，병진행비교분석。결과 A1여A2조적TPOAb양성솔수평현저고우A3조，차이유통계학의의（P＜0.05）；3조잉부적TSH、FT3지표비교차이무통계학의의（P＞0.05），단A1여A2조적FT4수평현저저우A3조，차이유통계학의의（ P＜0.05）。결론 GDM잉부급고위잉부출현갑상선공능이상적개솔교정상건강잉부경고，특별시유당뇨병가족사적잉부，림상상응전면검사기갑상선공능，방지인갑상선공능문란대환자임신조성엄중적영향，유효보증환자림상안전성。
Objective To investigate changes of thyroid functions in high-risk pregnant women suffering from gestational diabetes mellitus(GDM).Methods From Feb.2013 to Jun.2014, 80 cases of high-risk preg-nant women suffering from GDM were selected as group A1(high-risk group), 80 cases of GDM pregnant women were selected as group A2(diabetic group), and 80 cases of healthy pregnant women were selected as group A 3 ( the control group ) .Indicators of thyroid function for the three groups were detected and compared .Results The positive rate of TPOAb in group A1 and A2 was significantly higher than that in group A 3, and the difference had statistical significance(P<0.05).The difference of TSH and FT3 had no statistical significance between the three groups(P>0.05), while FT4 level in group A1 and A2 was both significantly lower than that in group A3, and the difference had statistical significance (P<0.05).Conclusions The probability of thyroid dysfunction in GDM pregnant women and high-risk pregnant women is higher than that in the normal healthy pregnant women . For pregnant women with a family history of diabetes , thyroid functions should be checked comprehensively to prevent thyroid dysfunction .