中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
Journal of Endocrine Surgery
2015年
5期
411-414
,共4页
多囊卵巢综合征%绝经%心血管疾病
多囊卵巢綜閤徵%絕經%心血管疾病
다낭란소종합정%절경%심혈관질병
Polycystic ovary syndrome%Menopause%Cardiovascular disease
目的：探讨具有多囊卵巢综合征（ polycystic ovary syndrome ， PCOS）表型的绝经女性心血管疾病发生状况。方法试验设计属于前瞻性随访研究，以2005年1月1日至2007年12月31日期间东阳市人民医院妇科健康查体的绝经女性为研究对象。据有无PCOS表型将患者分为PCOS表型组（ n＝294）和非PCOS表型（n＝59）2组，并对患者心血管状况进行随访。生存率估算应用Kaplan-Meier法，组间生存率曲线差异采用log-rank检验，应用多变量Cox比例风险回归分析MACE的独立危险因素。结果非PCOS表型组有11例出现主要不良心血管事件（major adverse cardiac events，MACE），PCOS表型组有6例出现MACE。 Kaplan-Meier曲线表明PCOS表型组无MACE生存率显著下降（χ2＝4.957，P＝0.026）。多变量Cox比例风险回归分析发现高密度脂蛋白胆固醇（high density lipoprotein-cholesterol， HDL-C）较低、高敏C-反应蛋白（high sensitive C-reactive protein，hs-CRP）较高和存在PCOS表型是MACE的独立预测因素。结论 PCOS表型是绝经女性发生心血管疾病的独立危险因素，有助于进一步行危险分层分析，且提示P-COS与心血管疾病密切相关。
目的：探討具有多囊卵巢綜閤徵（ polycystic ovary syndrome ， PCOS）錶型的絕經女性心血管疾病髮生狀況。方法試驗設計屬于前瞻性隨訪研究，以2005年1月1日至2007年12月31日期間東暘市人民醫院婦科健康查體的絕經女性為研究對象。據有無PCOS錶型將患者分為PCOS錶型組（ n＝294）和非PCOS錶型（n＝59）2組，併對患者心血管狀況進行隨訪。生存率估算應用Kaplan-Meier法，組間生存率麯線差異採用log-rank檢驗，應用多變量Cox比例風險迴歸分析MACE的獨立危險因素。結果非PCOS錶型組有11例齣現主要不良心血管事件（major adverse cardiac events，MACE），PCOS錶型組有6例齣現MACE。 Kaplan-Meier麯線錶明PCOS錶型組無MACE生存率顯著下降（χ2＝4.957，P＝0.026）。多變量Cox比例風險迴歸分析髮現高密度脂蛋白膽固醇（high density lipoprotein-cholesterol， HDL-C）較低、高敏C-反應蛋白（high sensitive C-reactive protein，hs-CRP）較高和存在PCOS錶型是MACE的獨立預測因素。結論 PCOS錶型是絕經女性髮生心血管疾病的獨立危險因素，有助于進一步行危險分層分析，且提示P-COS與心血管疾病密切相關。
목적：탐토구유다낭란소종합정（ polycystic ovary syndrome ， PCOS）표형적절경녀성심혈관질병발생상황。방법시험설계속우전첨성수방연구，이2005년1월1일지2007년12월31일기간동양시인민의원부과건강사체적절경녀성위연구대상。거유무PCOS표형장환자분위PCOS표형조（ n＝294）화비PCOS표형（n＝59）2조，병대환자심혈관상황진행수방。생존솔고산응용Kaplan-Meier법，조간생존솔곡선차이채용log-rank검험，응용다변량Cox비례풍험회귀분석MACE적독립위험인소。결과비PCOS표형조유11례출현주요불양심혈관사건（major adverse cardiac events，MACE），PCOS표형조유6례출현MACE。 Kaplan-Meier곡선표명PCOS표형조무MACE생존솔현저하강（χ2＝4.957，P＝0.026）。다변량Cox비례풍험회귀분석발현고밀도지단백담고순（high density lipoprotein-cholesterol， HDL-C）교저、고민C-반응단백（high sensitive C-reactive protein，hs-CRP）교고화존재PCOS표형시MACE적독립예측인소。결론 PCOS표형시절경녀성발생심혈관질병적독립위험인소，유조우진일보행위험분층분석，차제시P-COS여심혈관질병밀절상관。
Objective To explore cardiovascular disease in postmenopausal women with polycystic ovary syndrome(PCOS) phenotype.Methods This study was a prospective follow-up study which included subjects with PCOS phenotype admitted from Jan.1st, 2005 to Dec.31st, 2007 in Gynecology Department of Dongyang People's Hospital.These subjects were divided into two groups according to the presence or absence of PCOS phe -notype and were followed .Kaplan-Meier method was used to estimate survival rate .The survival difference be-tween the two groups was compared using the log-rank test.Multivariate Cox proportional hazards regression was used to determine the independent risk factors of major adverse cardiac events ( MACE) .Results 11 patients in non-PCOS phenotype group had MACE , and 6 patients in PCOS phenotype group had MACE .PCOS phenotype group had a significantly decreased MACE-free survival(χ2 =4.957,P=0.026).Multivariate Cox proportional hazards regression analysis showed that low level of HDL-C, presence of PCOS phenotype and high level of hs-CRP were independent predictors for MACE .Conclusion PCOS phenotype is an independent risk factor for car-diovascular disease in postmenopausal women , help to make further risk stratification and shows cardiovascular disease is closely related to PCOS .
