CAJ | 학술논문

目的：评估CASIA SS-1000新型扫频OCT （SS-1000 OCT）测量正常人中央角膜厚度（CCT）的重复性，并与A型超声测厚仪结果进行比较，评估2种仪器的一致性。方法前瞻性研究。收集正常受检者62名，均由同一熟练操作者对受检者右眼进行测量，先采用非接触SS-1000 OCT，再使用A超重复测量角膜厚度。组内标准系数（ICC）、Bland-Altman及重复测量方差分析用于评估SS-1000 OCT测量 CCT 的重复性；配对 t 检验及 Bland-Altman 用于评估 SS-1000 OCT 与 A 超的一致性。结果SS-1000 OCT重复3次测量CCT的ICC为0.999，第1次与第2欠、第1次与第3次及第2次与第3次的95％一致性区间分别为-2.4~1.8μm、-2.8~2.1μm、-2.8~2.7μm，重复测量方差分析进行两两比较显示差异无统计学意义。 SS-1000 OCT及A超测量CCT的均值分别为（534.38±24.52）μm和（538.40±25.36）μm，二者95％一致性区间为-12.6~4.5μm。结论 SS-1000 OCT测量CCT具有很好的重复性，与A型超声测厚仪具有高度的一致性，在临床工作中，可以考虑相互替代。
목적：평고CASIA SS-1000신형소빈OCT （SS-1000 OCT）측량정상인중앙각막후도（CCT）적중복성，병여A형초성측후의결과진행비교，평고2충의기적일치성。방법전첨성연구。수집정상수검자62명，균유동일숙련조작자대수검자우안진행측량，선채용비접촉SS-1000 OCT，재사용A초중복측량각막후도。조내표준계수（ICC）、Bland-Altman급중복측량방차분석용우평고SS-1000 OCT측량 CCT 적중복성；배대 t 검험급 Bland-Altman 용우평고 SS-1000 OCT 여 A 초적일치성。결과SS-1000 OCT중복3차측량CCT적ICC위0.999，제1차여제2흠、제1차여제3차급제2차여제3차적95％일치성구간분별위-2.4~1.8μm、-2.8~2.1μm、-2.8~2.7μm，중복측량방차분석진행량량비교현시차이무통계학의의。 SS-1000 OCT급A초측량CCT적균치분별위（534.38±24.52）μm화（538.40±25.36）μm，이자95％일치성구간위-12.6~4.5μm。결론 SS-1000 OCT측량CCT구유흔호적중복성，여A형초성측후의구유고도적일치성，재림상공작중，가이고필상호체대。
Objective To assess the repeatability of central corneal thickness (CCT) measurements in healthy eyes by comparing measurements obtained with an SS-1000 swept-source optical coherence tomography (SS-1000 OCT) or by ultrasound pachymetry (USP); to evaluate the agreement between these two devices. Methods In this prospective study, CCT was recorded after consecutive measurements with SS-1000 OCT and then with USP by a single skilled operator in 62 right eyes of healthy subjects. Intraclass correlation coefficient (ICC), Bland-Altman plots and repeated-measures analysis of variance (ANOVA) were used to evaluate the repeatability of SS-1000 OCT. Paired t-tests and Bland-Altman plots were used to evaluate the agreement between the two devices. Results The ICC of the SS-1000 OCT measurements was 0.999. Bland-Altman plots showed excellent agreement between any two of the three measurements (95% limits of agreement were -2.4 to 1.8 μm, -2.8 to 2.1 μm, and -2.8 to 2.7 μm). There was no statistical significance found with repeated-measures ANOVA. The mean values of CCT obtained from the SS-1000 OCT and USP were 534.38 ±24.52 μm and 538.40 ±25.36 μm, respectively. 95% limits of agreement were -12.6 to 4.5 μm for these two devices. Conclusion The SS-1000 OCT shows excellent repeatability of CCT measurements in healthy eyes. High agreement between CCT measurements suggests that SS-1000 OCT and USP can be used interchangeably in normal subjects.