CAJ | 학술논문

目的：对在治疗十二指肠溃疡的过程中使用奥美拉唑等三联疗法的临床效果进行分析。方法随机从2013年3月～2014年6月来我院治疗十二指肠溃疡的患者中选出110例，将其随机分为两对比组和研究组，对比组采用单独服用奥美拉唑的方法进行治疗；研究组则使用联合奥美拉唑、阿莫西林以及克拉霉素三种药物的三联疗法进行治疗。分别在治疗前后记录患者血清胃泌素、血清生长抑素、血清胃蛋白酶原Ⅰ以及血清胃蛋白酶原Ⅱ的含量，并对两组患者治疗效果、腹痛消失时间以及病情复发率等进行分析。结果两组患者血清检测各项数据均较治疗前降低，但研究组下降程度优于对比组。同时研究组的治疗效果优于对比组，腹痛消失时间短于对比组，复发率低于对比组， P＜0.05，差异具有统计学意义。结论在治疗十二指肠溃疡的过程中，利用三联疗法能够有效提高治疗效果，降低复发率。
목적：대재치료십이지장궤양적과정중사용오미랍서등삼련요법적림상효과진행분석。방법수궤종2013년3월～2014년6월래아원치료십이지장궤양적환자중선출110례，장기수궤분위량대비조화연구조，대비조채용단독복용오미랍서적방법진행치료；연구조칙사용연합오미랍서、아막서림이급극랍매소삼충약물적삼련요법진행치료。분별재치료전후기록환자혈청위비소、혈청생장억소、혈청위단백매원Ⅰ이급혈청위단백매원Ⅱ적함량，병대량조환자치료효과、복통소실시간이급병정복발솔등진행분석。결과량조환자혈청검측각항수거균교치료전강저，단연구조하강정도우우대비조。동시연구조적치료효과우우대비조，복통소실시간단우대비조，복발솔저우대비조， P＜0.05，차이구유통계학의의。결론재치료십이지장궤양적과정중，이용삼련요법능구유효제고치료효과，강저복발솔。
Objective Analysis the curative effect of omeprazole triple therapy in treatment of duodenal ulcer. Methods Randomly selected from 110 cases with duodenal ulcer March 2013 to June 2014 in our hospital, were divided into the control group and the study group, the control group took omeprazole treatment, the study group used combined omeprazole, amoxicillin and clarithromycin triple therapy for treatment of the three drugs. recorded before and after therapy in patients with gastric secrete element, serum somatostatin, serum pepsinogenⅠ and serum pepsinogenⅡcontent, and the therapeutic effect in both groups, abdominal pain disappear time and disease recurrence rate were analyzed.Results Two groups of patients with serum all the data before the treatment had lower, but the team drop degree was better than that the control group, the effect of the treatment of patients with team is better than the control group at the same time, abdominal pain disappear time was shorter than the control group, the recurrence rate was lower than the control group. Large differences between the two groups of data,P<0.05, had difference statistically signiifcance.Conclusion The process of treatment of duodenal ulcer, using triple therapy can effectively improve the treatment effect, reduce the chances of recurrence.