CAJ | 학술논문

目的：探讨宫颈癌超声造影特征与预后因素的关系。方法回顾性分析35例经病理证实为宫颈癌患者的超声造影增强特征和时间-强度曲线参数的特点,并与细胞核增殖抗原 ki-67的表达、肿瘤大小、淋巴结转移及病理分级进行比较。结果(1)与周围正常组织相比,宫颈癌病灶达峰时间(time to peak,TTP)明显缩短,峰值强度(peak intensity,PI)显著增高,差异具有统计学意义(P <0.05)；(2)血流灌注缺损及非均匀性增强的比率在 ki-67表达阳性、直径≥2.0 cm 及低分化的肿瘤中较高(P <0.05)；(3)与ki-67表达阴性者比较,ki-67表达阳性者 TTP 明显缩短,PI 显著升高,差异具有统计学意义(P <0.05)；(4)与高-中分化宫颈癌比较,低分化者 PI 明显升高,差异具有统计学意义(P <0.05)。结论宫颈癌超声造影特征与预后因素有一定的关系,有助于无创性评估宫颈癌的预后。
목적：탐토궁경암초성조영특정여예후인소적관계。방법회고성분석35례경병리증실위궁경암환자적초성조영증강특정화시간-강도곡선삼수적특점,병여세포핵증식항원 ki-67적표체、종류대소、림파결전이급병리분급진행비교。결과(1)여주위정상조직상비,궁경암병조체봉시간(time to peak,TTP)명현축단,봉치강도(peak intensity,PI)현저증고,차이구유통계학의의(P <0.05)；(2)혈류관주결손급비균균성증강적비솔재 ki-67표체양성、직경≥2.0 cm 급저분화적종류중교고(P <0.05)；(3)여ki-67표체음성자비교,ki-67표체양성자 TTP 명현축단,PI 현저승고,차이구유통계학의의(P <0.05)；(4)여고-중분화궁경암비교,저분화자 PI 명현승고,차이구유통계학의의(P <0.05)。결론궁경암초성조영특정여예후인소유일정적관계,유조우무창성평고궁경암적예후。
Objective To evaluate the relationship between characteristics of cervical cancer at contrast-enhanced ultrasound and prognostic factors.Methods Thirty-five patients with pathologically confirmed cervical cancer were enrolled in this retrospective analysis.All the patients accepted contrast-enhanced ultrasound examination before the surgery.Relationships between the characters of contrast-enhanced ultrasound and the expression of ki-67 antigen(cell proliferation marker),tumor diameter,lymph node metastasis and histologic grade were studied.Results (1)Compared to the surrounding normal tissue, the cervical cancer had statistically significant differences in time to peak and peak intensity(P <0.05),the former was shortened,and the latter was increased.(2 )The ratio of perfusion defect and heterogeneous enhancement were significantly higher in tissues,including the ki-67 positive expression tissue,poorly differentiated or larger tumors (≥ 2.0 cm in diameter)(P < 0.05 ).(3 )Compared to the ki-67 negative expression group,time to peak of the ki-67 positive expression group was shorter and the peak intensity was higher,the differences were statistically significant (P < 0.05 ).(4 )The peak intensity of poorly differentiated cervical cancers was significantly higher than that of the other groups (P <0.05).Conclusions Enhancement patterns and parameters of contrast-enhanced ultrasound were associated with prognosis, which may be useful in noninvasive prediction of the patients with cervical cancers.