CAJ | 학술논문

目的：观察分析依帕司他片治疗糖尿病并发周围神经病变的临床疗效。方法将2011年5月～2015年3月自我院进行治疗的糖尿病并发周围神经病变的120例患者作为试验对象，根据随机原则将所有患者分为观察组和对照组，每组60例。观察组在常规维持血糖的治疗同时服用依帕司他片，而对照组在常规治疗基础上给予注射维生素B12，治疗后对比两组患者的临床疗效。结果经过治疗后观察组临床总有效率达到了86.7%，而对照组仅有70.0%，观察组优于对照组，P＜0.05，差异具有统计学意义；且治疗前两组患者神经传导速度相比， P＞0.05，差异不具有统计学意义。治疗后，所有患者传导速度均高于治疗前，且观察组提升程度高于对照组，P＜0.05，差异具有统计学意义。结论对于糖尿病并发周围神经病变采用依帕司他片治疗能够提升临床疗效和神经传导速度。
목적：관찰분석의파사타편치료당뇨병병발주위신경병변적림상료효。방법장2011년5월～2015년3월자아원진행치료적당뇨병병발주위신경병변적120례환자작위시험대상，근거수궤원칙장소유환자분위관찰조화대조조，매조60례。관찰조재상규유지혈당적치료동시복용의파사타편，이대조조재상규치료기출상급여주사유생소B12，치료후대비량조환자적림상료효。결과경과치료후관찰조림상총유효솔체도료86.7%，이대조조부유70.0%，관찰조우우대조조，P＜0.05，차이구유통계학의의；차치료전량조환자신경전도속도상비， P＞0.05，차이불구유통계학의의。치료후，소유환자전도속도균고우치료전，차관찰조제승정도고우대조조，P＜0.05，차이구유통계학의의。결론대우당뇨병병발주위신경병변채용의파사타편치료능구제승림상료효화신경전도속도。
Objective To observe the clinical effect of Epalrestat Tablets in treating diabetic peripheral neuropathy.MethodsSelected 120 cases of diabetic patients with peripheral neuropathy from May 2011 to March 2015 in our hospital, were randomly divided into the observation group and the control group, each group had 60 cases. the observation group in the routine maintenance for treatment of blood glucose while taking epalrestat company, while the control group in conventional treatment on the basis of given injections of vitamin B12, after treatment, compared two groups of patients with clinical curative effect.ResultsAfter treatment, the observation group clinical total effective rate was 86.7%, and the control group was 70.0%, the observation group was better than the control group, P<0.05, had difference statistically signiifcance. And compared the nerve conduction velocity of two group,P>0.05, had no difference statistically signiifcance, after treatment, all patients were higher than before, and the observation group was higher than the control group,P<0.05, had difference statistically signiifcance.Conclusion For diabetic peripheral neuropathy by epalrestat company tablets in the treatment signiifcantly improved clinical efifcacy and nerve conduction velocity.