中国继续医学教育
中國繼續醫學教育
중국계속의학교육
China Continuing Medical Education
2015年
29期
183-184
,共2页
四氢叶酸钙%甲氨喋呤%急性淋巴细胞性白血病%儿童%解救
四氫葉痠鈣%甲氨喋呤%急性淋巴細胞性白血病%兒童%解救
사경협산개%갑안첩령%급성림파세포성백혈병%인동%해구
Calcium folinate%Methotrexate%Acute lymphoblastic leukemia%Children%Deal with
目的：探讨急性淋巴细胞性白血病（ALL）患儿应用大剂量甲氨喋呤（HD-MTX）化疗后小剂量四氢叶酸钙（CF）解救的可能性及护理体会。方法将17例确诊急性淋巴细胞性白血病中危型患儿的66例次HD-MTX-CF化疗随机分为观察组和对照组，减少观察组的36例次的HD-MTX化疗后CF的解救剂量至1.5%，对照组的30例次解救剂量仍为常规的3.5%。观察所有患儿的毒副反应，并监测血药浓度。结果对照组的30例化疗中有2例出现口腔黏膜溃烂，3例出现呕吐；观察组的36例化疗中，有2例出现口腔黏膜溃烂，5例出现呕吐，P＞0.05，差异不具有统计学意义。结论在严格进行各项护理操作、同时检测MTX血药浓度的情况下，应用小剂量四氢叶酸钙解救急性淋巴细胞性白血病患儿比较安全。
目的：探討急性淋巴細胞性白血病（ALL）患兒應用大劑量甲氨喋呤（HD-MTX）化療後小劑量四氫葉痠鈣（CF）解救的可能性及護理體會。方法將17例確診急性淋巴細胞性白血病中危型患兒的66例次HD-MTX-CF化療隨機分為觀察組和對照組，減少觀察組的36例次的HD-MTX化療後CF的解救劑量至1.5%，對照組的30例次解救劑量仍為常規的3.5%。觀察所有患兒的毒副反應，併鑑測血藥濃度。結果對照組的30例化療中有2例齣現口腔黏膜潰爛，3例齣現嘔吐；觀察組的36例化療中，有2例齣現口腔黏膜潰爛，5例齣現嘔吐，P＞0.05，差異不具有統計學意義。結論在嚴格進行各項護理操作、同時檢測MTX血藥濃度的情況下，應用小劑量四氫葉痠鈣解救急性淋巴細胞性白血病患兒比較安全。
목적：탐토급성림파세포성백혈병（ALL）환인응용대제량갑안첩령（HD-MTX）화료후소제량사경협산개（CF）해구적가능성급호리체회。방법장17례학진급성림파세포성백혈병중위형환인적66례차HD-MTX-CF화료수궤분위관찰조화대조조，감소관찰조적36례차적HD-MTX화료후CF적해구제량지1.5%，대조조적30례차해구제량잉위상규적3.5%。관찰소유환인적독부반응，병감측혈약농도。결과대조조적30례화료중유2례출현구강점막궤란，3례출현구토；관찰조적36례화료중，유2례출현구강점막궤란，5례출현구토，P＞0.05，차이불구유통계학의의。결론재엄격진행각항호리조작、동시검측MTX혈약농도적정황하，응용소제량사경협산개해구급성림파세포성백혈병환인비교안전。
Objective To discuss the possibility of small dose calcium folinate (CF) dealing with the bed effect caused by high dose methotrexate (HD-MTX) treating children with acute lymphoblastic leukemia (ALL) and the nursing care.Methods Selected 17 cases of the ALL patients were treated 66 using HD-MT. The treatments divided into two groups randomly, the observe group had 36 cases and the control group 30 cases. The observe group were given the dose of CF 1.5% after treating by HD-MTX, the control group were given the dose of CF 3.5% after treating by HD-MTX. collected the side effects and monitored the blood concentration.Results There were 5 emesis and 2 oral ulcer of the observe group and 3 emesis and 2 oral ulcer of the control group,P>0.05, had difference statistically signiifcance.Conclusion It was safe to use small dose CF dealing with the side effect casing by HD-MTX under monitoring MTX blood concentration and nursing carefully.
