CAJ | 학술논문

目的：探究应用塞来昔布治疗骨关节炎患者的临床效果及其安全性。方法选取我院2010年5月～2015年5月院接收骨关节炎患者89例，按照住院时间顺序依次编号，对照组44例接受双氯芬酸钠双释放肠溶胶囊治疗，试验组45例接受塞来昔布治疗，比较两组患者的临床疗效及不良反应发生率。结果两组患者经过系统治疗后，临床症状基本得到改善，对照组临床总有效率为47.73%，试验组为86.67%；术后对照组总并发症发生率90.91%，高于试验组总并发症发生率31.11%，试验组的安全性高于对照组的安全性，P＜0.05，差异具有统计学意义。结论对于骨关节炎患者应用塞来昔布药物的临床效果更佳，有较高的痊愈概率，不良反应发生的概率较小，临床效果更佳。
목적：탐구응용새래석포치료골관절염환자적림상효과급기안전성。방법선취아원2010년5월～2015년5월원접수골관절염환자89례，안조주원시간순서의차편호，대조조44례접수쌍록분산납쌍석방장용효낭치료，시험조45례접수새래석포치료，비교량조환자적림상료효급불량반응발생솔。결과량조환자경과계통치료후，림상증상기본득도개선，대조조림상총유효솔위47.73%，시험조위86.67%；술후대조조총병발증발생솔90.91%，고우시험조총병발증발생솔31.11%，시험조적안전성고우대조조적안전성，P＜0.05，차이구유통계학의의。결론대우골관절염환자응용새래석포약물적림상효과경가，유교고적전유개솔，불량반응발생적개솔교소，림상효과경가。
Objective Analysis security and clinical curative effect of application celecoxib in patients with osteoarthritis.Methods Selected 89 cases with osteoarthritis from May 2010 to May 2015 in our hospital. the control group had 44 cases were given diclofenac sodium dual release enteric-coated capsules. the observation group had 45 cases were given celecoxib. Compared the clinical effect and adverse reaction rate of the two groups.Results Clinical symptoms approved after treatment, total effective rate of control group was 47.73%, and observation group was 86.67%. Total complication rate of control group was 90.91% after treatment, obviously higher than observation group 31.11%. Safety of observation group was higher than control group,P<0.05, had difference statistically signiifcance. Conclusion Celecoxib in treating osteoarthritis has better clinical effect and higher cure rate, lower adverse reaction rate.