CAJ | 학술논문

微小RNA(micro RNA，miRNA)是一类长度为19~25 nt的单链非编码RNA，研究发现其具有多种生物学功能，调控大多数的细胞生物学进程。随着研究的深入，miRNA的功能及其调控网络也得到了进一步的认识。miR-125a是最近研究较多的miRNA，其主要作为抑癌基因发挥抑制肿瘤生长、转移的作用。本文简要综述了miR-125a与相关疾病的研究进展，以期全面了解miR-125a的生物学功能及作用靶点，为miR-125a的临床应用提供理论依据。
미소RNA(micro RNA，miRNA)시일류장도위19~25 nt적단련비편마RNA，연구발현기구유다충생물학공능，조공대다수적세포생물학진정。수착연구적심입，miRNA적공능급기조공망락야득도료진일보적인식。miR-125a시최근연구교다적miRNA，기주요작위억암기인발휘억제종류생장、전이적작용。본문간요종술료miR-125a여상관질병적연구진전，이기전면료해miR-125a적생물학공능급작용파점，위miR-125a적림상응용제공이론의거。
microRNA (miRNAs) is short non-coding RNA molecules with length of 19~25 nt. Previous studiesfind that it has a variety of biological functions, and it regulates most cell process. With further research on miRNAs, more and more functions have been discovered and characterized. miR-125a is a hot point of miRNAs researches, and it works as a tumor suppressor to inhibit growth and metastasis of tumor cell. This review focuses on the advances in miR-125a functions and related diseases, which will help us fully understand the biological function and target of miR-125a, in order to provide theoretical basis for the clinical application of miR-125a.