CAJ | 학술논문

目的：探讨维生素D受体VDR基因(包括BsmⅠ，ApaⅠ，TaqⅠ位点)多态性与中国成年男性骨密度的相关性。方法采用Meta分析方法，通过Pubmed、Embase、Cochrane、中国知网、维普网医学文献搜索引擎检索1990-2014年VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点多态性与我国大陆多地区、香港及台湾男性骨密度相关性的研究，评价纳入研究质量，提取有效数据后采用Review Manager 5.1进行Meta分析。选择固定效应模型，计算95%置信区间(95% confidence interval，95%CI)，效应量加权均数(weighted mean difference，WMD)。结果纳入8篇质量评价得分为4~6的文献，1934例中国成年男性，VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点多态性与股骨颈、大转子和Ward's三角区骨密度的相关性差异无统计学意义。考虑到地域差异，剔除中国香港和台湾地区，发现中国大陆地区成年男性VDR基因BsmⅠ多态性与股骨颈骨密度存在一定相关性(95%CI为0.03[0.00，0.06]，P=0.03)。结论 VDR基因BsmⅠ、ApaⅠ、TaqⅠ位点的多态性与中国多地区男性骨密度无明显相关性。
목적：탐토유생소D수체VDR기인(포괄BsmⅠ，ApaⅠ，TaqⅠ위점)다태성여중국성년남성골밀도적상관성。방법채용Meta분석방법，통과Pubmed、Embase、Cochrane、중국지망、유보망의학문헌수색인경검색1990-2014년VDR기인BsmⅠ、ApaⅠ、TaqⅠ위점다태성여아국대륙다지구、향항급태만남성골밀도상관성적연구，평개납입연구질량，제취유효수거후채용Review Manager 5.1진행Meta분석。선택고정효응모형，계산95%치신구간(95% confidence interval，95%CI)，효응량가권균수(weighted mean difference，WMD)。결과납입8편질량평개득분위4~6적문헌，1934례중국성년남성，VDR기인BsmⅠ、ApaⅠ、TaqⅠ위점다태성여고골경、대전자화Ward's삼각구골밀도적상관성차이무통계학의의。고필도지역차이，척제중국향항화태만지구，발현중국대륙지구성년남성VDR기인BsmⅠ다태성여고골경골밀도존재일정상관성(95%CI위0.03[0.00，0.06]，P=0.03)。결론 VDR기인BsmⅠ、ApaⅠ、TaqⅠ위점적다태성여중국다지구남성골밀도무명현상관성。
Objective To explore the associations between vitamin D receptor (VDR) gene polymorphisms (including BsmⅠ, ApaⅠand TaqⅠ) and bone mineral density (BMD) in Chinese men.Methods Databases including PubMed, Embase, Cochrane, CNKI and cqvip were retrieved to identify eligible studies (1990-2014). The quality of the included studies was evaluated and the data were extracted. Review Manager 5.1 was used for meta-analysis. Weighted mean difference (WMD) and 95% confidence intervals were calculated by usingfixed-effect model.Results A total of 8 studies were included in this meta-analysis, including 1 934 Chinese adult men. Theresults of meta-analysis showed that VDR BsmⅠ, ApaⅠ, TaqⅠpolymorphisms were not related to bone mineral density in Chinese men (including men in Taiwan and Hong Kong). Excluded men in Hong Kong and Taiwan analysis indicated that VDR gene BsmⅠpolymorphisms were associated with femoral neck BMD in mainland Chinese men (95%CI: 0.03[0.00,0.06],P=0.03).Conclusion The present study shows that VDR BsmⅠ, ApaⅠ, TaqⅠpolymorphisms are not associated with bone mineral density in Chinese men.