中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
Chinese Journal of Hepatobiliary Surgery
2015年
10期
674-677
,共4页
谭勇%邱宝安%孟宇宏%祝建勇%夏念信%杨英祥%刘鹏%周阳
譚勇%邱寶安%孟宇宏%祝建勇%夏唸信%楊英祥%劉鵬%週暘
담용%구보안%맹우굉%축건용%하념신%양영상%류붕%주양
肝外胆管癌%去整合素-金属蛋白酶17%高表达%临床病理参数%预后
肝外膽管癌%去整閤素-金屬蛋白酶17%高錶達%臨床病理參數%預後
간외담관암%거정합소-금속단백매17%고표체%림상병리삼수%예후
Extrahepatic cholangiocarcinoma%ADAM17%Overexpression%Clinicopathological parameters%Prognosis
目的 探讨去整合素-金属蛋白酶17(ADAM17)表达与肝外胆管癌临床病理特征的联系,评估ADAM17过表达是否与肝外胆管癌患者的预后相关.方法 使用免疫组化染色检测78例肝外胆管癌患者ADAM17表达情况,分析肝外胆管癌组织ADAM17表达水平与患者临床病理参数以及手术预后的关系.结果 肝外胆管癌组织ADAM17表达水平显著高于癌旁组织(P＜0.05),ADAM17高表达与患者临床病理参数如肿瘤大小、T分期、淋巴结转移和血管侵犯显著相关(P＜0.05).单因素分析显示ADAM17高表达与手术预后差显著相关(P＜0.05),ADAM17高表达与肝外胆管癌根治性切除术后总体生存呈负相关(P＜0.05).多因素COX分析结果显示,ADAM17高表达是肝外胆管癌术后总体生存的独立预后因素.结论 ADAM17过度表达可能参与了肝外胆管癌的侵袭和进展,且与肝外胆管癌患者手术预后差相关.
目的 探討去整閤素-金屬蛋白酶17(ADAM17)錶達與肝外膽管癌臨床病理特徵的聯繫,評估ADAM17過錶達是否與肝外膽管癌患者的預後相關.方法 使用免疫組化染色檢測78例肝外膽管癌患者ADAM17錶達情況,分析肝外膽管癌組織ADAM17錶達水平與患者臨床病理參數以及手術預後的關繫.結果 肝外膽管癌組織ADAM17錶達水平顯著高于癌徬組織(P＜0.05),ADAM17高錶達與患者臨床病理參數如腫瘤大小、T分期、淋巴結轉移和血管侵犯顯著相關(P＜0.05).單因素分析顯示ADAM17高錶達與手術預後差顯著相關(P＜0.05),ADAM17高錶達與肝外膽管癌根治性切除術後總體生存呈負相關(P＜0.05).多因素COX分析結果顯示,ADAM17高錶達是肝外膽管癌術後總體生存的獨立預後因素.結論 ADAM17過度錶達可能參與瞭肝外膽管癌的侵襲和進展,且與肝外膽管癌患者手術預後差相關.
목적 탐토거정합소-금속단백매17(ADAM17)표체여간외담관암림상병리특정적련계,평고ADAM17과표체시부여간외담관암환자적예후상관.방법 사용면역조화염색검측78례간외담관암환자ADAM17표체정황,분석간외담관암조직ADAM17표체수평여환자림상병리삼수이급수술예후적관계.결과 간외담관암조직ADAM17표체수평현저고우암방조직(P＜0.05),ADAM17고표체여환자림상병리삼수여종류대소、T분기、림파결전이화혈관침범현저상관(P＜0.05).단인소분석현시ADAM17고표체여수술예후차현저상관(P＜0.05),ADAM17고표체여간외담관암근치성절제술후총체생존정부상관(P＜0.05).다인소COX분석결과현시,ADAM17고표체시간외담관암술후총체생존적독립예후인소.결론 ADAM17과도표체가능삼여료간외담관암적침습화진전,차여간외담관암환자수술예후차상관.
Objective To investigate the relationship between the expression of ADAM17 and the clinicopathological parameters of extrahepatic cholangiocarcinoma (ECC), and to correlate the overexpression of ADAM17 with prognoses of patients with ECC.Method The expressions of ADAM17 in 78 patients with ECC from the Navy General Hospital were detected by immunohistochemical staining and the relationships between the ADAM17 expression and the clinicopathological parameters, and the prognosis of patients with ECC after resection were analyzed.Resets The expression of ADAM17 was higher in cancer tissues than their adjacent tissues (P ＜ 0.05).A high expression of ADAM17 was significantly correlated with tumour size, T classification, lymph node metastasis, and vascular invasion (P ＜ 0.05).Univariate analysis revealed a high expression of ADAM17 was significantly related with poor prognosis after resection (P ＜0.05), a high expression of ADAM17 was inversely associated with overall survival for patients with ECC after curative resection (P ＜ 0.05).Multivariate COX analysis indicated a high expression of ADAM17 was an independent prognostic factor of overall survival for patients with ECC after resection.Conclusion Overexpression of ADAM17 was correlated with invasion, progression of ECC and with a poor prognosis in patients with ECC after resection.
