临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
32期
7-8,14
,共3页
直肠癌根治术%复方斑蝥胶囊%抗肿瘤化学治疗
直腸癌根治術%複方斑蝥膠囊%抗腫瘤化學治療
직장암근치술%복방반모효낭%항종류화학치료
Rectal cancer radical operation%Fufangbanmao capsules%Anti tumor chemotherapy
目的：探讨复方斑蝥胶囊联合化疗用于直肠癌根治术后的临床效果。方法选取2012年6月-2015年6月普外科直肠癌术后1个月行化疗并联合服用复方斑蝥胶囊的患者88例作为 A 组，选取同期行单纯化疗患者98例为 B 组。观察、比较2组患者近期临床疗效及生活质量改善情况、不良反应及成本—效果比。结果 A 组总有效率为44.32%明显高于 B 组的30.61%，但差异无统计学意义（P ﹥0.05）。A 组 PD 进展率为18.18%明显低于B 组的34.69%，差异有统计学意义（P ﹤0.05）。A 组生活改善率为69.31%明显优于 B 组的56.12%，差异有统计学意义（P ﹤0.05）。A 组除肝酶异常发生率外，余胃肠道反应、神经毒性、骨髓抑制、脱发、肝酶异常等不良反应发生率均明显低于 B 组，差异有统计学意义（P ﹤0.05）。A 组具有更高的药物治疗经济性。结论直肠癌术后辅助应用复方斑蝥胶囊联合化疗可以提高治疗效果，改善生活质量，不良反应发生率低，且更安全、经济。值得临床推广应用。
目的：探討複方斑蝥膠囊聯閤化療用于直腸癌根治術後的臨床效果。方法選取2012年6月-2015年6月普外科直腸癌術後1箇月行化療併聯閤服用複方斑蝥膠囊的患者88例作為 A 組，選取同期行單純化療患者98例為 B 組。觀察、比較2組患者近期臨床療效及生活質量改善情況、不良反應及成本—效果比。結果 A 組總有效率為44.32%明顯高于 B 組的30.61%，但差異無統計學意義（P ﹥0.05）。A 組 PD 進展率為18.18%明顯低于B 組的34.69%，差異有統計學意義（P ﹤0.05）。A 組生活改善率為69.31%明顯優于 B 組的56.12%，差異有統計學意義（P ﹤0.05）。A 組除肝酶異常髮生率外，餘胃腸道反應、神經毒性、骨髓抑製、脫髮、肝酶異常等不良反應髮生率均明顯低于 B 組，差異有統計學意義（P ﹤0.05）。A 組具有更高的藥物治療經濟性。結論直腸癌術後輔助應用複方斑蝥膠囊聯閤化療可以提高治療效果，改善生活質量，不良反應髮生率低，且更安全、經濟。值得臨床推廣應用。
목적：탐토복방반모효낭연합화료용우직장암근치술후적림상효과。방법선취2012년6월-2015년6월보외과직장암술후1개월행화료병연합복용복방반모효낭적환자88례작위 A 조，선취동기행단순화료환자98례위 B 조。관찰、비교2조환자근기림상료효급생활질량개선정황、불량반응급성본—효과비。결과 A 조총유효솔위44.32%명현고우 B 조적30.61%，단차이무통계학의의（P ﹥0.05）。A 조 PD 진전솔위18.18%명현저우B 조적34.69%，차이유통계학의의（P ﹤0.05）。A 조생활개선솔위69.31%명현우우 B 조적56.12%，차이유통계학의의（P ﹤0.05）。A 조제간매이상발생솔외，여위장도반응、신경독성、골수억제、탈발、간매이상등불량반응발생솔균명현저우 B 조，차이유통계학의의（P ﹤0.05）。A 조구유경고적약물치료경제성。결론직장암술후보조응용복방반모효낭연합화료가이제고치료효과，개선생활질량，불량반응발생솔저，차경안전、경제。치득림상추엄응용。
Objective To explore the clinical effect of chemotherapy combined with Fufang Banmao capsule after rad-ical resection of rectal cancer treatment. Methods 88 cases of postoperative rectal cancer with chemotherapy combined with Fufang Banmao capsule treated patients were selected as A group,98 patients who received chemotherapy only were selected as B group. The short-term clinical curative effect,life quality improvement,adverse reactions and cost-effectiveness ratio of the 2 groups were compared. Results The total effective rate of A group was 30. 61% ,which was significantly higher than that of B group(P ﹥ 0. 05). The progression rate of PD in A group was 34. 69% ,which was significantly lower than that in B group (P ﹤ 0. 05). The improvement rate of life quality in A group was 56. 12% ,which was significantly better than that in B group (P ﹤ 0. 05). In addition to the abnormal liver enzymes,gastrointestinal reactions,neurotoxicity,bone marrow suppression,hair loss,liver enzyme abnormalities and other adverse reactions were significantly lower in A group than in B group,the difference was statistically significant(P ﹤ 0. 05). The A group had a higher drug economy. Conclusion Chemotherapy combined with Fufang Banmao capsule used in rectal cancer radical therapy can improve the therapeutic effect and improve the quality of life and adverse reactions occur rate is low,more economical,it is worth of clinical application.
